TLDR Male pattern hair loss affects up to 80% of men due to genetics and hormone sensitivity.
Male pattern hair loss (MPHL) affected up to 80% of men over their lifetime and was characterized by a progressive reduction in hair diameter, length, and pigmentation, primarily in the frontal, temporal, and vertex areas of the scalp. This condition resulted from the effects of dihydrotestosterone (DHT), a testosterone metabolite, on androgen-sensitive hair follicles. The sensitivity to androgens was genetically determined and depended on DHT production through 5-alpha reductase enzymes.
Hormonal treatments can help with hair loss, acne, and excess hair growth, but it takes 3-6 months to see results and patients should know the possible side effects.
36 citations,
June 2018 in “Journal of Dermatology” Use finasteride, dutasteride, and minoxidil for hair loss treatment.
March 2025 in “JAAD reviews.” Bicalutamide can reduce female pattern hair loss, especially in those with certain conditions, but has limited effects on other hair loss types.
58 citations,
September 2012 in “Dermatologic Clinics” Male pattern hair loss caused by follicular miniaturization; early diagnosis and treatment can reduce psychological burden.
3 citations,
May 2018 in “Journal of nutritional health & food science” Nutritional supplements can help manage hair loss and promote hair growth by strengthening hair roots and countering harmful effects of pollution, smoking, and deficiencies in vitamins and minerals.
