Nonscarring Alopecias: Male Pattern Hair Loss

June 2015 in “ CRC Press eBooks ”

Colombina Vincenzi, Antonellá Tosti

male pattern hair loss MPHL dihydrotestosterone DHT androgen-sensitive hair follicles 5-alpha reductase enzymes male pattern baldness testosterone metabolite

TLDR Male pattern hair loss affects up to 80% of men due to genetics and hormone sensitivity.

Male pattern hair loss (MPHL) affected up to 80% of men over their lifetime and was characterized by a progressive reduction in hair diameter, length, and pigmentation, primarily in the frontal, temporal, and vertex areas of the scalp. This condition resulted from the effects of dihydrotestosterone (DHT), a testosterone metabolite, on androgen-sensitive hair follicles. The sensitivity to androgens was genetically determined and depended on DHT production through 5-alpha reductase enzymes.

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