research Targeted Therapy in Melanoma
New treatments for advanced skin cancer are improving patient outcomes, but drug resistance and finding the right treatment combinations are still big challenges.
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research Receptor Activator of NF-κB Stimulates the Proliferation of Epithelial Cells of the Epidermo-Pilosebaceous Unit
RANK-RANKL signaling is essential for hair growth and skin health.
research Controlling Hair Loss by Regulating Apoptosis in Hair Follicles: A Comprehensive Overview
Regulating cell death in hair follicles can help prevent hair loss and promote hair growth.
research Cucurbitacin Promotes Hair Growth in Mice by Inhibiting the Expression of Fibroblast Growth Factor 18
Cucurbitacin helps mice grow hair by blocking a protein that stops hair growth.
research Canine Follicle Stem Cell Candidates Reside in the Bulge and Share Characteristic Features with Human Bulge Cells
Canine hair follicles have stem cells similar to human hair follicles, useful for studying hair disorders.
research Melatonin Protects K15+ Human Hair Follicle Stem Cells and Hair Matrix Keratinocytes Against Paclitaxel-Induced Damage Ex Vivo
Melatonin may protect hair follicle cells from damage caused by a chemotherapy drug.
research Loss-Of-Function Mutations of an Inhibitory Upstream ORF in the Human Hairless Transcript Cause Marie Unna Hereditary Hypotrichosis
Certain mutations in a hair growth-related gene cause a type of genetic hair loss.
research Cutaneous Toxicities From Transplantation-Related Medications
Skin problems from transplant drugs are common and need careful management in organ transplant patients.
research Refractory Folliculitis Decalvans Treatment Success with a Novel Surgical Excision Approach Using Guarded High-Tension Sutures
A new surgical method using special sutures significantly reduced wound size and prevented disease return in patients with a scarring scalp condition.
research Biomaterials for Dermal Substitutes
The document concludes that a complete skin restoration biomaterial does not yet exist, and more clinical trials are needed to ensure these therapies are safe and effective.
research Benign Cutaneous Eruptions After Transplantation
Transplant patients often get skin problems, with treatments varying by condition.
research Cicatricial Alopecia: Diagnosis and Treatment Overview
Cicatricial alopecia causes permanent hair loss and is treated to relieve symptoms and stop progression.
research Human Skin Stem Cells and the Aging Process
Skin aging is due to impaired stem cell mobilization or fewer responsive stem cells.
research Progressive Alopecia Reveals Decreasing Stem Cell Activation Probability During Aging of Mice with Epidermal Deletion of DNA Methyltransferase 1
Mice lacking a key DNA methylation enzyme in skin cells have a lower chance of activating stem cells necessary for hair growth, leading to progressive hair loss.
research Neuroendocrinology of Epithelial Hair Follicle Stem Cells
Hormones and neuroendocrine factors control hair growth and color, and more research could lead to new hair treatment options.
research Hair Follicle Regeneration in Skin Grafts: Current Concepts and Future Perspectives
Hair follicle regeneration in skin grafts may be possible using stem cells and tissue engineering.
research Impact of Adipose-Derived Stem Cells on Engineering Hair Follicle Germ-Like Tissue Grafts for Hair Regenerative Medicine
Adding human fat-derived stem cells to hair follicle grafts greatly increases hair growth.
research Primary Cicatricial Alopecias
The document concludes that early diagnosis and treatment are crucial for managing rare hair loss disorders and that more research is needed to improve treatment strategies.
research Psychosocial Impact of Cicatricial Alopecias
Most patients with cicatricial alopecias face significant psychological and social challenges due to their hair loss.
research Scarring Alopecias: Pathology and an Update on Digital Developments
New digital tools are improving the diagnosis and understanding of irreversible hair loss conditions.
research Androgenic Alopecia: Pathogenetic Mechanisms and Therapeutic Approaches
The document concludes that current treatments for androgenic alopecia are not fully effective, but new therapies like botulinum toxin and PRP show promise, and future gene therapy could be beneficial.
research A Clinical and Biological Guide for Understanding Chemotherapy-Induced Alopecia and Its Prevention
Scalp cooling can help prevent chemotherapy-induced hair loss with a 50-90% success rate and is safe for patients.
research Pre-Clinical Cell-Based Therapy for Limbal Stem Cell Deficiency
Cell-based therapies show promise for treating Limbal Stem Cell Deficiency but need more research.
research Androgenetic Alopecia: Pathogenetic Mechanisms and Treatment Approaches
Androgenic alopecia, a common hair loss condition, is linked to changes in androgen metabolism and genetics, and can be treated with finasteride and minoxidil, but these treatments are only fully effective in 10% of patients.
research Cutaneous Side Effects of Chemotherapy and Radiotherapy
Chemotherapy and radiotherapy can cause skin side effects like rashes, hair loss, and nail changes, which are usually managed with conservative treatments.
research Primary Scarring Alopecias: Review of Histopathological Findings of 37 Patients from the Department of Dermatology at the Hospital das Clínicas, Faculty of Medicine, University of São Paulo from 2000 to 2005
Accurate diagnosis of cicatricial alopecias requires thorough scalp examination and multiple biopsy techniques.
research Folliculocentric Papules and Alopecia in a 70-Year-Old Woman Diagnosed with Graham-Little-Piccardi-Lassueur Syndrome
A 70-year-old woman with a rare skin condition improved after treatment with topical steroids and acitretin.
research When Bugs and Drugs Conspire: Driving Acneiform Skin Toxicity
Certain cancer drugs interact with skin bacteria to cause acne-like rashes.
research Trichodysplasia Spinulosa: A Benign Adnexal Proliferation with Follicular Differentiation Associated with Polyomavirus
Trichodysplasia spinulosa is a rare skin condition caused by a virus, treatable with antiviral medication.
research Cicatricial Alopecia: Classification and Histopathology
Early detection and histopathology are crucial to prevent permanent hair loss in cicatricial alopecia.