August 2025 in “Journal of Cosmetic Dermatology” This review explores low-level light therapy's potential as a noninvasive treatment for various forms of alopecia, noting its promising results in hair regrowth and density but highlighting the need for standardized protocols and further research.
20 citations
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March 2014 in “PubMed” This review describes recent advances in the study of epidermal stem cells and their importance in regenerative medicine and skin tissue engineering, but provides no new clinical results.
10 citations
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May 2012 in “Journal of Plastic Reconstructive and Aesthetic Surgery” This article discusses various methods for minimizing and repairing strip scars from follicular unit hair transplants but reports no new clinical results.
112 citations
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October 2008 in “Wound Repair and Regeneration” This study demonstrated that disrupting sonic hedgehog signaling, using cyclopamine, significantly impaired wound healing in a mouse model, suggesting its crucial role in postnatal tissue repair.
2 citations
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May 2010 in “Hair transplant forum international” This article discusses methods for repairing undesirable aesthetic hairlines from prior hair transplants and reports no new findings.
This review discusses recent advances in using stem cells for skin repair and regeneration after severe burn injuries, but it reports no new clinical results.
February 2025 in “International Journal of Biological Macromolecules” This study developed a NIR light-triggered NO-releasing hydrogel that promotes angiogenesis, repairs damaged dermal papilla cells, reduces inflammation, and improves the nutrient supply and follicular environment in animal models, offering a promising treatment strategy for androgenic alopecia.
February 2026 in “SHILAP Revista de lepidopterología” This study demonstrated that engineered exosomes loaded with growth factors, EGF and FGF, could successfully repair the hair follicle microenvironment in an androgenetic alopecia mouse model, enhancing hair growth without causing adverse immune reactions or toxicity.
37 citations
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August 2013 in “Facial Plastic Surgery Clinics of North America” This review discusses facial hair transplantation techniques for natural-appearing results in restoring eyebrows, beards, goatees, sideburns, and repairing alopecic scarring, reporting no new clinical results.
February 2026 in “The Animal Biology” In this animal study, Hirudo verbana leech extract significantly improved hair follicle regeneration and accelerated wound healing in rats, demonstrating potential as a safe and effective agent for skin repair due to its bioactive compounds with regenerative and anti-inflammatory properties.
January 2014 in “Plastic Surgery” In this study, the authors describe a new technique using the Ventralex hernia patch for simultaneous umbilical hernia repair during abdominoplasty, observing its application in 11 female patients.
4 citations
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January 2015 in “Experimental Dermatology” This study developed a humanized scalp model in mice which demonstrated that transplanted cultured human hair follicle dermal cells contributed to the restoration of damaged hair follicles.
2 citations
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May 2023 in “Experimental dermatology” In this study, researchers used advanced four-dimensional optical imaging techniques to observe changes in skin afflicted with acne, finding increased epidermal thickness, keratinized hair follicles, inflammation, and aggregated blood flow, helping to distinguish between inflammation and reparative phases of acne progression.
1010 citations
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August 2000 in “Cell” In this study, researchers found that hair follicle stem cells in mice can generate both hair follicle and epidermis cells, highlighting their potential bipotency.
September 2025 in “Journal of Cutaneous and Aesthetic Surgery” This case report demonstrated that long-hair follicular unit extraction may effectively reconstruct the mustache area following surgical scarring, with high patient satisfaction and no complications observed.
156 citations
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October 2012 in “Seminars in Cell & Developmental Biology” This study found that hair follicle stem cells initially contribute to wound re-epithelialization, but long-lasting epidermal cells are primarily derived from a stem cell population in the isthmus portion of hair follicles.
14 citations
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October 2020 in “Scientific reports” This study found that ATM protein plays a crucial role in protecting human hair follicle melanocytes from oxidative stress, which is linked to the greying of hair.
11 citations
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January 2010 in “Indian Journal of Dermatology, Venereology and Leprology” Hair transplant and applying 5% minoxidil solution can effectively treat permanent hair loss, but it may change hair direction in some cases.
3 citations
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August 2011 in “InTech eBooks” This article discusses the applications and contraindications of skin grafts in wound treatment and reports no new research findings.
April 2026 in “Clinical Cosmetic and Investigational Dermatology” This review highlights the varied therapeutic applications of punch-based techniques in dermatologic surgery, noting consistent evidence for follicular unit extraction in androgenetic alopecia, but more mixed results for scar treatment, vitiligo, and chronic wounds, warranting further standardized research.
May 2025 in “Preprints.org” This review discusses the dermatological potential of olive mill wastewater as a sustainable source of high-value cosmeceutical ingredients but reports no new clinical results.
January 2026 in “International Journal of Biological Macromolecules” The hydrogel improves hair growth treatment by enhancing drug delivery and promoting follicle repair.
March 2015 in “Zagazig University Medical Journal” The study found that CK15 expression, representing hair follicle stem cell activity, was reduced or absent in scarred primary cicatricial alopecia lesions, suggesting stem cell damage may contribute to the scarring process.
30 citations
,
March 2008 in “Wound Repair and Regeneration” This study found that estrogen affected cell behaviors differently in a scratch-wound assay, increasing VEGF secretion in follicular dermal papilla cells but decreasing it in wounded dermal sheath cells.
4 citations
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May 2009 in “Wound Repair and Regeneration” This study found that transplanting genetically modified dermal fibroblasts into full-thickness skin defects in rats led to the formation of hair follicles with mature pilosebaceous systems by 16 weeks.
March 2024 in “Revista Argentina de de Cirugía Plástica Estética y Reparadora” In this study, researchers describe the FUE method of hair micrografting, which involves extracting and implanting follicular units using advanced tools, leading to more natural results, quicker recovery, and less damage to donor sites.
10 citations
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June 2016 in “Wound Repair and Regeneration” This review explores the regenerative potential of hair follicles and their role in complete skin regeneration, emphasizing the influence of mechanical factors and niche signaling pathways on hair growth and loss.
63 citations
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October 2012 in “Wound Repair and Regeneration” This study found that transplanting autologous scalp follicular grafts into chronic leg ulcers led to a greater reduction in ulcer size compared to non-grafted areas, suggesting a promising therapeutic alternative.
41 citations
,
August 2013 in “Facial Plastic Surgery Clinics of North America” This article discusses the benefits, techniques, and unique considerations of follicular unit extraction for hair grafting, but reports no new clinical results.
11 citations
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September 2001 in “The Cleft Palate Craniofacial Journal” This case report describes successful moustache restoration in an 18-year-old with a cleft lip scar using single-follicular-unit graft hair transplantation, highlighting its application in corrective cosmetic surgeries.