11 citations
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January 1993 in “Dermatology” In this study, researchers found histopathological similarities between L-tryptophan eosinophilic myalgia syndrome and idiopathic eosinophilic fasciitis, with certain unique inflammatory features present in the former.
33 citations
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September 2020 in “Current Rheumatology Reports” This review discusses the emerging role of AMT in fibrosis and suggests that targeting AMT could offer a novel approach to treatment; it reports no new clinical results.
March 2013 in “Hair transplant forum international” This article discusses the role of inflammation in causing various types of alopecia but reports no clinical results; the author notes an ongoing interest in the topic.
33 citations
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January 2001 in “Critical care clinics” This article reviews the roles and synthesis of essential long-chain fatty acids in the body and reports no new research findings; it emphasizes the importance of dietary sources for these lipids.
January 2023 in “SSRN Electronic Journal” This study found that a fibroin-based cosmetic ingredient improved the mechanical properties and cuticle repair of African-American and Caucasian hair types, even when damaged by chemical treatments.
In this retrospective study, researchers at a Spanish hospital found that the severity of frontal fibrosing alopecia, primarily affecting postmenopausal women, was correlated with the duration of the disease, though inflammatory signs were not linked with its progression.
15 citations
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November 2024 in “Journal of Advanced Research” In this study, researchers found that miR-3606-3p is significantly downregulated in skin fibrosis and correlates with disease severity, with its ability to inhibit key signaling pathways suggesting potential therapeutic applications for conditions like systemic sclerosis and keloids.
146 citations
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July 2018 in “Regenerative Medicine” This review updates the understanding of fibroblast heterogeneity in wound healing, discussing advancements in fibroblast roles and potential therapies, but it reports no new clinical results.
222 citations
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August 2014 in “Cell Metabolism” In this study, researchers found that mitochondrial complex I plays a crucial role in regulating innate immunity and bone remodeling, with Ndufs4 deletion causing systemic inflammation and osteopetrosis through various metabolic shifts and cellular mechanisms.
1 citations
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September 2004 in “Experimental Dermatology” This study found that α-melanocyte-stimulating hormone may modulate inflammation in skin connective tissue by inhibiting proinflammatory effects in fibroblasts.
June 2026 in “Frontiers in Immunology” This review synthesizes both traditional and emerging molecular mechanisms of tissue remodeling across different organs, aiming to establish a theoretical basis for precision interventions in pathological conditions, according to the authors.
September 2023 in “International Journal of Dermatology” In this study, FAPD was characterized in a Chinese population by perifollicular mast cell infiltration, suggesting young individuals may be at higher risk than previously thought.
June 2020 in “International Journal of Women’s Dermatology” This case report highlights the importance of considering frontal fibrosing alopecia in young women, emphasizing early diagnosis to preserve hair and limit inflammation.
7 citations
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January 2019 in “Dermatology Online Journal” In this case report, a 62-year-old woman's persistent frontal fibrosing alopecia while on the psoriasis medication ustekinumab suggests that IL-12 and IL-23 inhibition may not be effective in treating this scarring alopecia, challenging the role of Th1 and Th17 pathways in its pathogenesis.
88 citations
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August 2019 in “Frontiers in immunology” This review discusses the role of tyrosine kinase signaling pathways in autoimmune and inflammatory skin diseases and reports no new clinical results, highlighting ongoing research into small-molecule tyrosine kinase inhibitors as potential treatments.
This study reported that prompt diagnosis and treatment with 5-alpha-reductase inhibitors and topical immunomodulators are key to mitigating the effects of frontal fibrosing alopecia and preventing permanent hair loss.
This review discusses the role of fibroblast growth factors and their receptors in maintaining and repairing epithelial tissues, highlighting their importance in epithelial homeostasis and response to injuries without reporting new clinical results.
7 citations
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September 2019 in “Journal of The American Academy of Dermatology” This study found inflammation and fibrosis in both pattern hair loss cases and controls but concluded that these factors may not significantly contribute to the pathogenesis of pattern hair loss.
38 citations
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January 2019 in “International Journal of Women's Dermatology” This review discusses potential therapeutic options for frontal fibrosing alopecia by exploring distinct signaling pathways and cellular players, but reports no new clinical findings and emphasizes the need for further trials.
January 2016 in “Indian dermatology online journal” This case report describes a 50-year-old woman with frontal fibrosing alopecia who showed no improvement despite multiple treatments, including intralesional triamcinolone and topical glucocorticoids.
In this study, researchers developed a multifunctional hydrogel for wound healing, incorporating antibacterial and antioxidant properties that demonstrated significant inflammation reduction and tissue regeneration in animal models, with high antibacterial efficacy against E. coli and S. aureus.
March 2022 in “Más dermatología” This report discusses the potential overlap between chronic cutaneous lupus and frontal fibrosing alopecia, noting ongoing debate over the significance of their association without presenting new clinical results.
8 citations
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July 2017 in “The journal of investigative dermatology/Journal of investigative dermatology” This study identified four circulating microRNAs as highly predictive of frontal fibrosing alopecia status, suggesting potential roles in diagnostics and disease understanding.
July 2022 in “British Journal of Dermatology” This study found that epidermal growth factor receptor inhibitors used in cancer treatment induce a distinct inflammatory response in hair follicles, marked by immune privilege collapse and upregulation of inflammatory pathways.
12 citations
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December 2021 in “Fundamental Research” This study found that (-)-blebbistatin significantly inhibited liver fibrosis in mouse models by reducing tissue stiffness and myofibroblast activation, indicating potential for developing broad-spectrum antifibrotic drugs.
68 citations
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March 2018 in “Biomaterials” This study found that fibronectin nanofiber dressings, made using rotary jet spinning, accelerated wound healing and improved tissue restoration in a full-thickness wound mouse model.
May 2025 in “The Journal of Rheumatology” This case report describes a 32-year-old Filipino female with mixed connective tissue disease who sequentially developed distinct autoimmune disorders over seven years, highlighting the complexities in diagnosis and management of overlap syndromes.
2 citations
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February 2018 in “InTech eBooks” This article discusses adverse immune-mediated skin reactions associated with TNF-alpha inhibitors, highlighting paradoxical reactions such as psoriasis that occur despite being treated with medications intended to alleviate the condition.
November 2024 in “Thrombosis Journal” This review highlights potential links between inflammatory skin diseases like psoriasis and atopic dermatitis and hypercoagulable states, but notes that more research is needed to understand these connections and their clinical implications.
April 2023 in “Journal of Investigative Dermatology” This study found that dimethyl fumarate improved delayed wound healing in Il36rn-/- mice by reducing neutrophil extracellular trap formation and oxidative stress.