Clinically Compatible Lesions With Frontal Fibrosing Alopecia in Patients With Chronic Lupus Erythematosus: Expanding the Spectrum of Overlap Syndrome

March 2022 in “ Más dermatología ”

Francisco Javier del Boz González, J.F. Millán‐Cayetano

frontal fibrosing alopecia chronic cutaneous lupus alopecia lupus erythematosus

TLDR Chronic lupus and frontal fibrosing alopecia can occur together, but their connection is unclear.

The document discussed the overlap between chronic cutaneous lupus (CCL) and frontal fibrosing alopecia (FFA), both of which were common conditions. It highlighted that while there was a reported overlap between these two entities, there was still controversy regarding the significance of this association. The study aimed to expand the understanding of the overlap syndrome between CCL and FFA.

View this study on doi.org →

Discuss this study in the Community →

Research cited in this study

7 / 7 results

research Frontal Fibrosing Alopecia and Discoid Lupus Erythematosus: More Than a Coincidence

April 2019 in “Actas Dermo-Sifiliográficas”

The conclusion is that having both Frontal Fibrosing Alopecia and Discoid Lupus Erythematosus may suggest a shared immune response in certain people, and a mix of antimalarial drugs and 5-alfa-reductase inhibitors is recommended for treatment.

research Coexistence of Chronic Cutaneous Lupus Erythematosus and Frontal Fibrosing Alopecia

12 citations , March 2018 in “Anais brasileiros de dermatologia/Anais Brasileiros de Dermatologia”

A patient had both chronic cutaneous lupus erythematosus and frontal fibrosing alopecia.

research Updated Diagnostic Criteria for Frontal Fibrosing Alopecia

30 citations , December 2017 in “Journal of The American Academy of Dermatology”

New criteria for diagnosing frontal fibrosing alopecia include specific scalp and eyebrow hair loss as major factors and other hair loss areas and hair analysis as minor factors.

research Frontal Fibrosing Alopecia Coexisting With Lupus Erythematosus: Poor Response To Hydroxychloroquine

12 citations , January 2016 in “Skin Appendage Disorders”

Hydroxychloroquine is ineffective for treating frontal fibrosing alopecia with lupus erythematosus.

research Frontal Fibrosing Alopecia: A Multicenter Review of 355 Patients

5 citations , March 2014 in “Journal of The American Academy of Dermatology”

The study suggests hormonal factors may play a role in Frontal Fibrosing Alopecia and that treatments like oral antiandrogens and steroids could be beneficial.

research Frontal Fibrosing Alopecia: A Multicenter Review of 355 Patients

339 citations , February 2014 in “Journal of The American Academy of Dermatology”

Most patients with frontal fibrosing alopecia are postmenopausal women, and treatments like finasteride and dutasteride can improve or stabilize the condition.

research Discoid Lupus Alopecia Complicated by Frontal Fibrosing Alopecia on a Background of Androgenetic Alopecia

25 citations , March 2013 in “British Journal of Dermatology”

Woman has discoid lupus, frontal fibrosing, and androgenetic alopecia.

Related Community Posts Join

6 / 586 results

community A Different Take on Curing MBP

16 upvotes 6 years ago

Addressing hair loss by focusing on posture, blood flow, and craniofacial development. Methods include improving posture, cardiovascular activity, scalp massages, healthy diet, meditation, using minoxidil, and addressing craniofacial issues.

community DUPA/Retrograde might not be DHT based...GET A BIOPSY QUICK or permanent Hair Loss!

in Research/Science 43 upvotes 9 months ago

DUPA and retrograde alopecia may not be solely DHT-based, and a biopsy is crucial for accurate diagnosis and treatment. Treatments mentioned include dutasteride, oral minoxidil, pioglitazone, clobetasol, calcipotriol, ketoconazole, and doxycycline, depending on the specific condition.

community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

in Research 830 upvotes 1 year ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community 1 and a half years on fin - hair is way worse.

in Finasteride/Dutasteride 9 upvotes 2 years ago

The user reported worsening hair loss after 1.5 years on finasteride, questioning if chronic iron deficiency could be a cause. They noted no side effects from finasteride.

community I think I’ve finally found the reason for my hair loss

in Chat 98 upvotes 11 months ago

The user experienced hair loss since 2019 and tried finasteride, dutasteride, RU58841, and ketoconazole shampoo without success. A scalp biopsy showed scarring and inflammation from folliculitis, indicating chronic inflammation was affecting treatment effectiveness.

community How essential is scalp biopsy when dealing with hair loss?

in Treatment 6 upvotes 1 year ago

The user experienced hair loss despite using Fin and Min for 12 years and switched to Dutasteride, RU58841, and Keto scalp serum, but shedding and itch persist. They are considering increasing Dutasteride to 2.5mg and questioning the necessity of a scalp biopsy, with mixed opinions on its usefulness.

Similar Research

6 / 1000+ results

Reply to ‘CD123 Immunohistochemistry for Plasmacytoid Dendritic Cells Is Useful in the Diagnosis of Scarring Alopecia’: Three PDC-Related Parameters Are Useful in Differentiating Lupus Alopecia from LPP

research Reply to ‘CD123 Immunohistochemistry for Plasmacytoid Dendritic Cells Is Useful in the Diagnosis of Scarring Alopecia’: Three PDC-Related Parameters Are Useful in Differentiating Lupus Alopecia from LPP

4 citations , November 2016 in “Journal of Cutaneous Pathology”

Three characteristics of plasmacytoid dendritic cells help tell apart lupus-related hair loss from LPP.

research Recent Insight on the Management of Lupus Erythematosus Alopecia

3 citations , March 2021 in “Clinical, Cosmetic and Investigational Dermatology”

Early treatment of Lupus Erythematosus Alopecia can prevent permanent hair loss, and various medications are effective.

research Scarring Alopecia: Overview and Treatment Options

1 citations , June 2012 in “Actas Dermo-Sifiliográficas”

Early and aggressive treatment of scarring alopecia is important to prevent further hair follicle damage.

research Non-Neoplastic Disorders of Hair

January 2010 in “Elsevier eBooks”

The document concludes that different types of hair loss have specific treatments, and early diagnosis is crucial for preventing permanent hair loss.

research Autoimmune Disease and Hair Loss

35 citations , October 2012 in “Dermatologic Clinics”

Autoimmune diseases can cause hair loss, and early treatment is important to prevent permanent damage.

research Coexistence of Chronic Cutaneous Lupus Erythematosus and Frontal Fibrosing Alopecia

12 citations , March 2018 in “Anais brasileiros de dermatologia/Anais Brasileiros de Dermatologia”

A patient had both chronic cutaneous lupus erythematosus and frontal fibrosing alopecia.