Frontal Fibrosing Alopecia and Discoid Lupus Erythematosus: More Than a Coincidence

    April 2019 in “ Actas Dermo-Sifiliográficas ”
    Pablo Fernández-Crehuet, Ricardo Ruiz-Villaverde
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    TLDR The conclusion is that having both Frontal Fibrosing Alopecia and Discoid Lupus Erythematosus may suggest a shared immune response in certain people, and a mix of antimalarial drugs and 5-alfa-reductase inhibitors is recommended for treatment.
    The document from 2019 presents a case of a 57-year-old woman who showed symptoms of both Frontal Fibrosing Alopecia (FFA) and Discoid Lupus Erythematosus (DLE), two conditions that are rarely seen together. The patient had diffuse hair loss, inflammatory plaques in alopecic areas, and hair loss on the arms and eyebrows. The study suggests that the simultaneous presence of FFA and DLE could indicate a common immunological pathway in genetically predisposed individuals. The patient was also taking enalapril, a drug linked to lichenoid eruptions and cutaneous lupus, but no cases were found supporting a relationship with FFA. The study concluded that monotherapy with hydroxychloroquine or chloroquine was not effective, and recommended a combination of antimalarial agents with 5-alfa-reductase inhibitors for treatment.
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