Laboratory and Clinical Hemostatic Aberrations in Primary Dermatologic Disease: A Review

    November 2024 in “ Thrombosis Journal
    Divya Sharma, Sierra Thomas, Trace B Moody, Mitchell A. Taylor, Bianca Ituarte, Corey J Georgeson, Christopher D. Barrett, Erin X. Wei
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    Studysummary This review highlights potential links between inflammatory skin diseases like psoriasis and atopic dermatitis and hypercoagulable states, but notes that more research is needed to understand these connections and their clinical implications.
    Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
    This review explores the relationship between inflammatory dermatologic diseases, such as alopecia areata and psoriasis, and their potential links to thromboembolic and hypercoagulable states. Current literature suggests a possible connection between these skin diseases and systemic inflammation, which may lead to cardiovascular comorbidities. Biomarkers like F1 + 2, D-dimer, and PAI-1 are being studied to understand these links, but more research is needed to draw definitive conclusions. The review highlights the need for further investigation into the molecular mechanisms and clinical outcomes of these traditionally "skin limited" diseases to improve patient care.
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