Is the Severity of Alopecia Areata Associated with Arterial Stiffness?

November 2023 in “ Journal of Research in Medical Sciences ”

Mohammad Taghi Najafi, Robabeh Abedini, Narges Ghandi, Shadab Seraji, Yasaman Sadeghi

alopecia areata metabolic syndrome arterial stiffness cardiovascular diseases cardiometabolic diseases

Studysummary This study found that patients with AA who have more severe symptoms may have a higher risk of metabolic syndrome and arterial stiffness, suggesting a need for cardiometabolic disease screening.

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Research cited in this study

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research Metabolic Syndrome and Skin Diseases

40 citations , November 2019 in “Frontiers in Endocrinology”

This review discusses the links between metabolic syndrome and various skin diseases, exploring shared mechanisms such as insulin resistance and inflammation, but reports no new clinical results.

research Alopecia Areata: A Multifactorial Autoimmune Condition

148 citations , December 2018 in “Journal of autoimmunity”

This review discusses genetic and environmental factors contributing to autoimmunity in alopecia areata and reports no new clinical findings, emphasizing the need for further study on its aetiology and pathophysiology.

research Alopecia Areata Is Associated With Increased Expression of Heart Disease Biomarker Cardiac Troponin I

19 citations , January 2018 in “Acta dermato-venereologica”

In this study, the researchers observed that subjects with alopecia areata had the highest plasma level of cardiac troponin I, followed by those with androgenetic alopecia, and the lowest levels in individuals without hair loss.

research Alopecia Areata: Overview and Insights from January 2018

290 citations , December 2017 in “Journal of The American Academy of Dermatology”

This article reviews the epidemiology, clinical evaluation, and pathogenesis of alopecia areata and highlights recent advancements, but it does not report new clinical findings.

research Alopecia and the Metabolic Syndrome

30 citations , September 2017 in “Clinics in Dermatology”

This review explores the relationship between androgenetic alopecia and metabolic syndrome, suggesting an association that supports considering cardiovascular risk assessments in patients with this type of hair loss.

research Health-Related Quality of Life Among Patients With Alopecia Areata: A Systematic Review

95 citations , July 2016 in “Journal of The American Academy of Dermatology”

This review concluded that patients with alopecia areata consistently show poor health-related quality of life scores, similar to those in other chronic skin diseases like atopic dermatitis and psoriasis.

research Familial Aggregation of Alopecia Areata

295 citations , May 2016 in “Journal of the American Academy of Dermatology”

This review examines the immunological aspects of alopecia areata, focusing on genetic, neuroimmunological, and immune privilege factors, but does not report new clinical findings.

research Cardiovascular Risk in Patients with Alopecia Areata: A Propensity-Matched Retrospective Analysis

29 citations , May 2016 in “Journal of the American Academy of Dermatology”

This study observed that patients with alopecia areata had decreased odds of developing stroke and a potential decreased risk of acute myocardial infarction, though the latter was not statistically significant.

research Epidemiology and Burden of Alopecia Areata: A Systematic Review

144 citations , July 2015 in “Clinical, Cosmetic and Investigational Dermatology”

This review reports that alopecia areata affects about 2% of people globally and is linked with psychiatric and medical comorbidities, highlighting its significant disease burden.

research Alopecia Areata Increases the Risk of Stroke: A 3-Year Follow-Up Study

25 citations , June 2015 in “Scientific Reports”

In this study, patients with alopecia areata were found to have a higher risk of stroke over a 3-year follow-up period compared to those without the condition.

research Androgenetic Alopecia, Metabolic Syndrome, and Insulin Resistance: Is There Any Association? A Case-Control Study

34 citations , January 2014 in “Indian Dermatology Online Journal”

This study supports evaluating metabolic syndrome and insulin resistance in young males with advanced androgenic alopecia to potentially reduce future cardiovascular and type 2 diabetes risks.

research Association Between Alopecia Areata, Psoriasis Vulgaris, Thyroid Disease, And Metabolic Syndrome

17 citations , December 2013 in “Journal of Investigative Dermatology Symposium Proceedings”

This report describes two young women with severe psoriasis and alopecia universalis, highlighting the possible but unstudied association between alopecia areata and metabolic syndrome.

research Development of Autoimmune Hair Loss Disease Alopecia Areata Is Associated with Cardiac Dysfunction in C3H/HeJ Mice

18 citations , April 2013 in “PLOS ONE”

This study found that in a mouse model, alopecia areata was associated with changes in heart structure, biochemistry, and gene expression linked to cardiac hypertrophy after ACTH exposure.

research Androgenetic Alopecia and Cardiovascular Risk Factors in Men and Women: A Comparative Study

110 citations , July 2010 in “Journal of The American Academy of Dermatology”

Hair loss linked to higher heart disease risk in both men and women.

research Androgenetic Alopecia and Coronary Artery Disease in Women

37 citations , January 2005 in “Dermatology Online Journal”

In this study, researchers observed a significant association between female androgenetic alopecia and coronary artery disease in women under 55, supporting a link similar to that seen in men.