Melanocortin Receptors in Fibroblastic Cell Types of the Skin: In Vitro and In Vivo Expression and Functional Relevance
September 2004
in “
Experimental Dermatology
”
TLDR MC-1R is present in skin cells and may help reduce inflammation.
The study explored the expression and functional relevance of melanocortin receptors (MC‐Rs), specifically MC‐1R, in various fibroblastic cell types of the skin. It was found that MC‐1R expression was present both in vitro and in vivo in human fibroblastic cells, including adult dermal fibroblasts and dermal papilla cells of the hair follicle. The expression of MC‐1R decreased with cellular aging in dermal fibroblasts. Additionally, α‐melanocyte‐stimulating hormone (α‐MSH) was shown to inhibit the effect of interferon‐γ on the expression of adhesion molecules, suggesting a role for α‐MSH in modulating inflammatory responses in the skin's connective tissue.
