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    Glossary Melanocortin 1 Receptor

    regulates melanin production, affecting hair and skin color

    The Melanocortin 1 Receptor (MC1R) is a protein found on the surface of melanocytes, the cells responsible for producing melanin, the pigment that gives skin, hair, and eyes their color. Variations in the MC1R gene can influence hair color, skin tone, and susceptibility to UV radiation, and are also associated with red hair and fair skin.

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    Research 10 of 377

    1. Down-regulation of Melanocortin Receptor Signaling Mediated by the Amino Terminus of Agouti Protein in XenopusMelanophores Journal of Biological Chemistry · 1999 · 43 citations
    2. Melanocortin receptors in fibroblastic cell types of the skin –<i>in vitro</i> and <i>in vivo</i> expression and functional relevance Experimental Dermatology · 2004 · 1 citations
    3. Expression of melanocortin receptors on cutaneous fibroblastic cells – collagen and beyond Experimental Dermatology · 2005 · 1 citations
    4. Bone morphogenetic protein (BMP) signaling controls hair pigmentation by means of cross-talk with the melanocortin receptor-1 pathway Proceedings of the National Academy of Sciences · 2004 · 70 citations
    5. An implication for post-transcriptional control: Reciprocal changes of melanocortin receptor type 2 mRNA and protein expression in alopecia areata Medical Hypotheses · 2010 · 7 citations
    6. Melanocortin receptor type 2 (MC2R, ACTH receptor) expression in patients with alopecia areata Experimental Dermatology · 2010 · 22 citations
    7. Detection of Functionally Active Melanocortin Receptors and Evidence for an Immunoregulatory Activity of α-Melanocyte-Stimulating Hormone in Human Dermal Papilla Cells Endocrinology · 2005 · 60 citations
    8. Selected variants of the melanocortin 4 receptor gene (MC4R) do not confer susceptibility to female pattern hair loss Archives of Dermatological Research · 2012 · 9 citations
    9. Effect of Tribulus Terrestris Extract of Different Dosings on Melanocortin-1 Receptor Expression in Mouse Hair Follicles The Chinese Journal of Dermatovenereology · 2009
    10. Melanocortins in fibroblast biology – current update and future perspective for dermatology Experimental Dermatology · 2004 · 32 citations
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