January 2020 in “eScholarship (California Digital Library)” This study used multi-scale hybrid models to explore how signaling factors affect skin wound healing and embryo development, suggesting that different levels of fibrin clot density influence scar formation.
23 citations
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September 2020 in “Journal of Cosmetic Dermatology” This review discusses the potential applications of injectable platelet‐rich fibrin in various conditions and reports no new clinical results; the authors highlight its favorable use in comparison to existing treatments.
18 citations
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January 2019 in “International journal of trichology” This study found that injectable platelet-rich fibrin (i-PRF) showed improved hair growth in males with Type VI and Type VII alopecia, which are typically difficult to treat.
August 2021 in “International Journal of Dermatology and Venereology” This review discusses various potential applications of platelet-rich fibrin in dermatology, but reports no clinical results and highlights the need for standardized protocols.
66 citations
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June 2015 in “Aesthetic Plastic Surgery” This review of 47 studies indicates that platelet preparations may significantly enhance cellular activity, wound healing, and facial aesthetic outcomes in facial plastic surgery, though potential publication bias should be considered.
May 2024 in “Journal of Cosmetic and Laser Therapy” This study found that three sessions of injectable platelet-rich fibrin (i-PRF+) significantly improved hair follicle density, hair volume, and thickness, as well as patient satisfaction in women with female pattern hair loss, with only minor self-limited adverse effects reported.
April 2024 in “Journal of cosmetic dermatology” This article discusses the development of liquid platelet-rich fibrin as a potential improvement over platelet-rich plasma for treating androgenetic alopecia and reports no new clinical results.
733 citations
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September 2009 in “Journal of Cell Science” This article reviews the complex process of wound repair, emphasizing recent microarray studies and proteomic analyses, but reports no new clinical results.
5 citations
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April 2025 in “Journal of Functional Biomaterials” In this study, the addition of A-PRF+ to surgical protocols significantly improved bone healing and implant stability when combined with biomaterials, suggesting it as a viable option for patients concerned about using human- and animal-derived biomaterials.
This article introduces geriatric aesthetics and discusses the potential of platelet-rich plasma as a cost-effective solution in developing countries, but reports no new clinical results.
May 2024 in “International journal of molecular sciences” This review synthesizes evidence on platelet-derived bioproducts like PRP and PRF, highlighting their role in tissue regeneration and their benefits in aesthetic medicine applications such as hair restoration, scar treatment, and wound healing.
July 2024 in “Periodontology 2000” This review summarizes the use of autologous platelet concentrates in aesthetic medicine, finding promising results for facial treatments, but highlights the need for more rigorous research due to current study limitations.
27 citations
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April 2018 in “Artificial Cells Nanomedicine and Biotechnology” This study reported that recombinant human hair keratins, K37 and K81, showed higher purity and enhanced fibrin clot formation compared to traditional extracts, reducing bleeding time and blood loss in rat injury models.
January 2024 in “International Journal of Trichology” In this laboratory study, researchers found that human platelet-rich plasma (hPRP) significantly improved the proliferation and hair-inductive capacity of human dermal papilla cells (hDPCs) compared to fetal bovine serum, suggesting hPRP as a potential substitute for FBS in expanding hDPCs for clinical hair regeneration therapies.
March 2026 in “Trends in Sciences” This review suggests that while platelet-rich plasma has the most robust clinical evidence, platelet-rich fibrin and concentrated growth factors are gaining favor due to their ease of use and absence of additives.
December 2025 in “Eastern Ukrainian Medical Journal” This study reviews current methods for making and using platelet-rich plasma and fibrin, emphasizing the variability in clinical outcomes due to differences in preparation protocols, and calls for standardized guidelines and large-scale studies for better effectiveness in regenerative medicine.
4 citations
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April 2024 in “Cellular and Molecular Biology” In this study, injectable platelet-rich fibrin (i-PRF) was found to enhance the proliferative, migratory, and hair-inducing abilities of dermal papilla cells more effectively than platelet-rich plasma through the TGF-β/Smad pathway.
January 2025 in “Acta Clinica Croatica” This pilot study found that using platelet rich fibrin in combination with dressings after revascularization surgery in patients with critical limb ischemia accelerated wound healing compared to dressings alone.
May 2022 in “International Journal of Clinical Trials” This study concluded that platelet rich fibrin (PRF) may enhance healing and functional recovery compared to platelet rich plasma (PRP) during immediate post-extractive dental implant procedures.
This abstract suggests that cost barriers limit the application of standard aesthetic procedures in developing countries, while exploring platelet-rich plasma as a potentially safer and less invasive option in geriatric aesthetics. Detailed results were not reported.
363 citations
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March 2017 in “Nature Communications” This study found that, in mouse tail epidermis, stem cells rapidly activate and regenerate new progenitors to repair wounds, with mechanisms affecting their proliferation, differentiation, and migration.
In this book, the authors provide an accessible overview of platelet concentrates and their dental applications, highlighting their role in tissue healing and regeneration, and reviewing recent studies on their efficacy in periodontal therapy, implant dentistry, and oral surgery.
November 2025 in “PARIPEX-INDIAN JOURNAL OF RESEARCH” GFC is more effective than PRP for treating hair loss.
January 2019 in “Springer eBooks” Platelet-rich plasma therapy may have benefits and is generally safe, but more research is needed to confirm its effectiveness and safety.
March 2017 in “Open access journal of surgery” This review discusses the historical development of platelet-rich fibrin from fibrin glue to platelet-enriched formulations and reports no new clinical results.
119 citations
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January 2014 in “Indian Journal of Dermatology, Venereology and Leprology” This review discusses the use of platelet-rich plasma in various dermatological applications and reports no new clinical results; the authors call for more rigorous trials to confirm its effectiveness.
33 citations
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February 2019 in “Journal of Tissue Engineering and Regenerative Medicine” This review discusses the use of platelet-rich plasma for various dermatological conditions and highlights the need for more research to standardize its protocols and understand its biological mechanisms.
This study concluded that using Plasma gel and PRP as autologous collagen biostimulators improved acne scars and skin density, demonstrating efficiency and safety for facial rejuvenation in clinical evaluations including patient satisfaction.
November 2021 in “International Journal for Research in Applied Science and Engineering Technology” This review discusses the various applications of lyophilized platelet-rich plasma in treating different diseases and reports no new clinical results.
70 citations
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February 2017 in “Dermatologic Surgery” This study reports that plasma rich in growth factors appeared to improve hair follicle regeneration and patient satisfaction in individuals with androgenetic alopecia, though further trials are needed.