Advanced Platelet-Rich Fibrin Plus (A-PRF+) as an Additive to Hard Tissue Managing Protocols in Oral Surgery: A Systematic Review

This systematic review assesses the effectiveness of Advanced Platelet-Rich Fibrin Plus (A-PRF+) in oral surgery for hard tissue management, based on 10 randomized clinical trials involving 328 patients. A-PRF+ is shown to improve post-surgical alveolar ridge dimensions, bone composition, and implant stability, although it does not significantly affect mineral bone density compared to other materials. It enhances vital bone formation and reduces connective tissue presence, with notable improvements in implant stability as evidenced by PerioTest scores and insertion torque values. Despite variations in surgical protocols and the need for further research, A-PRF+ demonstrates potential as a beneficial additive in oral surgery, particularly for patients concerned about human- and animal-derived biomaterials.