252 citations
,
March 1998 in “Developmental dynamics” This study suggests that fibroblast growth factors FGF-4, FGF-8, and FGF-9 may play redundant roles as signals in epithelial-mesenchymal interactions during multiple stages of tooth development in mice.
243 citations
,
October 2003 in “Developmental biology” This study identified ectodin as a novel BMP inhibitor that modulates BMP signaling in ectodermal development by interacting with SHH and FGF pathways.
237 citations
,
June 2013 in “Nature Medicine” This study found that fibroblast growth factor 9, initially secreted by γδ T cells, plays a key role in modulating hair follicle regeneration in mice after skin wounds.
158 citations
,
February 2012 in “Journal of Investigative Dermatology” FGF18 helps keep hair in its resting phase, affecting hair growth cycles.
136 citations
,
July 2014 in “Proceedings of the National Academy of Sciences of the United States of America” This study identified mutations in the FGF5 gene as a cause of extreme eyelash growth in Pakistani families, highlighting a potential target for regulating eyelash growth.
104 citations
,
October 2016 in “PLoS ONE” This study found that CRISPR/Cas9-mediated disruption of the FGF5 gene in goats increased hair follicle numbers and fiber length, suggesting more cashmere production could be achieved.
103 citations
,
June 2018 in “International Journal of Molecular Sciences” This review discusses the applications and research on fibroblast growth factors, including their use in wound healing, diabetes, and cancer, but it reports no new clinical results.
84 citations
,
October 2014 in “PLoS Genetics” This study found that epidermal Wnt production is crucial for forming the skin's spinous layer through a BMP-FGF signaling cascade, although Wnt from basal cells is not needed for their differentiation.
66 citations
,
June 2004 in “Development” This study found that FGF signaling is necessary for the initiation of feather placode development in chicken embryos, with FGF10 being implicated as an early dermal signal in the process.
65 citations
,
September 2023 in “Cell Reports Medicine” This review examined the common side effects of FGFR inhibitors like erdafitinib, pemigatinib, and futibatinib, and detailed strategies for managing them, highlighting that proactive monitoring and appropriate interventions can effectively mitigate these toxicities.
65 citations
,
February 2009 in “The journal of investigative dermatology/Journal of investigative dermatology” This paper discusses the hypothesis that anti-acne agents may work by reducing FGFR2 signaling, and emphasizes FGFR2's potential role in acne pathogenesis, but it reports no new experimental findings.
63 citations
,
May 2009 in “Dermato-endocrinology” This review explores the role of FGFR2b-signaling in the pathogenesis of acne, highlighting its influence on sebaceous gland physiology and the effects of anti-acne agents like isotretinoin.
50 citations
,
February 2013 in “BMC evolutionary biology” This study found that the Hr gene loss and positive selection for the FGF5 gene in cetaceans likely contributed to hair loss as these animals adapted to aquatic environments.
50 citations
,
September 2012 in “Developmental Biology” This study found that over-expressing Spry4 and Fgf10 modulates feather stem cells to alter feather morphologies in distinct ways, affecting barb branch formation and tissue structure.
47 citations
,
June 2017 in “The FEBS journal” This study found that CRISPR/Cas9-induced loss-of-function mutations in the FGF5 gene significantly increased wool length and yield in genetically modified Chinese Merino sheep compared to wild-type controls.
45 citations
,
July 2009 in “Journal of human genetics” This study found that an SNP in the FGFR2 gene, rs4752566, was significantly associated with hair thickness in Asian populations, suggesting an effect on hair morphology through altered FGFR2 expression levels.
42 citations
,
September 2015 in “Gene” This study demonstrated that FGF5s acts as an inhibitor of FGF5 in regulating hair growth cycles in cashmere goat dermal papilla cells.
39 citations
,
May 2014 in “Frontiers in Pharmacology” In this study, CD4+CD25+FoxP3+ Regulatory T cells were found to reduce TGF-b1 induced lung fibrosis and fibrocyte accumulation in mice, partly by suppressing fibroblast growth factor 9.
29 citations
,
June 2014 in “Experimental Cell Research” This study found that treating mouse epidermal neural crest stem cells with EGF and FGF2 increased their proliferation and enhanced their neuronal differentiation potential.
27 citations
,
February 2017 in “Clinical, Cosmetic and Investigational Dermatology” In this study, a topical formulation with compounds from the monoterpenoid family significantly improved hair growth indicators like anagen:telogen ratio, hair fall, and visual hair density in men and women with pattern hair loss.
27 citations
,
September 2013 in “The FASEB Journal” This study reports that the loss of the protein Memo in mice leads to a reduced lifespan and suggests that Memo is a key regulator of FGFR signaling and vitamin D production.
24 citations
,
July 2017 in “Structure” In this study, researchers found that ligand homodimerization controls the receptor binding specificity of the FGF9 subfamily, preventing off-target activation of FGFR "b" isoforms.
23 citations
,
May 2023 in “Cell Proliferation” This review highlights the critical role of TGF-β and FGF signaling pathways in the development and regeneration of skin layers, particularly the dermis, and discusses their significance in advancing future clinical applications in dermatology.
23 citations
,
May 2020 in “Cell Death and Disease” This study generated FGF5-knockout Dorper sheep using the CRISPR/Cas9 system, resulting in significantly increased fine-wool and active hair-follicle density, and explored downstream signaling pathways for potential applications in androgen alopecia treatment.
23 citations
,
March 2019 in “Gene” In this study, researchers found that the evolutionary and structural features of the oFGF5 gene in sheep may influence hair follicle development and hair growth regulation.
21 citations
,
June 2016 in “PloS one” This study found that MYC and FGF pathways are crucial for hair cell regeneration in chick and zebrafish models, suggesting potential targets for promoting hair cell regeneration in mammals.
20 citations
,
January 2017 in “Scientific reports” This study found that cetaceans have adapted their fibroblast growth factors to assist in low bone density, hypoxia tolerance, and the development of rigid flippers, reflecting significant evolutionary changes for aquatic life.
19 citations
,
January 2015 in “Development” This study found that misexpression of Hoxc8 in mice led to ectopic mammary development and suggests Hox genes may play crucial roles in the regional specification and initiation of cutaneous accessory organs.
19 citations
,
November 2012 in “Cell Communication and Signaling” This study found that Fibroblast growth factor-9 (FGF-9) accelerates epithelial invagination in engineered ectodermal organs and suggests its potential role in organogenesis and regeneration research.
17 citations
,
September 2020 in “Inflammation and Regeneration” In this study, researchers found that WNT activation influenced FGF expression in human scalp-derived fibroblasts, with mouse model results showing FGF9 increased hair follicle number and diameter, while FGF7 reduced diameter.