75 citations,
August 2014 in “Journal of Investigative Dermatology” Aging mice have slower hair regeneration due to changes in signal balance, but the environment, not stem cell loss, controls this, suggesting treatments could focus on environmental factors.
43 citations,
November 2014 in “Experimental Dermatology” Hair follicles can help wounds heal faster and this knowledge could be used to treat chronic skin ulcers, with a potential use of a special stem cell hydrogel to enhance healing.
35 citations,
May 2017 in “Journal of Dermatological Science” Stress can cause early aging in certain skin cells, leading to problems with hair growth.
66 citations,
April 2016 in “Journal of Molecular Biology” The document concludes that for hair and feather growth, it's better to target the environment around stem cells than the cells themselves.
135 citations,
January 2016 in “Expert Opinion on Biological Therapy” Exosomes could potentially enhance tissue repair and regeneration with lower rejection risk and easier production than live cell therapies.
38 citations,
June 2019 in “International Journal of Molecular Sciences” Tiny particles called extracellular vesicles could help with skin healing and hair growth, but more research is needed.
8 citations,
January 2017 in “Stem Cells International” A protein called sFRP4 from skin cells stops the development of pigment-producing cells in hair.
August 2015 in “MOJ proteomics & bioinformatics” ePUKs could be valuable for regenerative medicine due to their wound healing abilities.
77 citations,
March 2021 in “Nature” Stress hormone corticosterone blocks a growth factor to slow down hair stem cell activity and hair growth.
65 citations,
January 2018 in “Nature Reviews Endocrinology” Skin fat has important roles in hair growth, skin repair, immune defense, and aging, and could be targeted for skin and hair treatments.
38 citations,
June 2017 in “The Journal of Dermatology” Aging in hair follicle stem cells leads to hair graying, thinning, and loss.
32 citations,
September 2016 in “Journal of Investigative Dermatology” STAT5 activation is crucial for starting the hair growth phase.
25 citations,
November 2016 in “The journal of investigative dermatology/Journal of investigative dermatology” Imiquimod cream activates hair follicle stem cells and causes early hair growth by changing immune cells and certain protein expressions.
23 citations,
December 2020 in “Frontiers in Cell and Developmental Biology” Gene network oscillations inside hair stem cells are key for hair growth regulation and could help treat hair loss.
19 citations,
June 2020 in “Animals” Poor maternal nutrition can lead to fewer wool follicles in Chinese Merino sheep.
19 citations,
July 2015 in “Developmental Dynamics” The conclusion is that skin and hair patterns are formed by a mix of cell activities, molecular signals, and environmental factors.
16 citations,
April 2015 in “Lasers in Surgery and Medicine” Using a fractional laser can stimulate hair growth, but the intensity and duration of inflammation are crucial. Too much can cause ulcers and scarring. Lower beam energy and fewer treatments are recommended to avoid damage.
14 citations,
January 2018 in “Scientific reports” Bioluminescence imaging can track hair follicle cells and help study hair regrowth.
13 citations,
January 2018 in “Cellular Physiology and Biochemistry” Fat-derived stem cells can help protect and repair skin stem cells from aging caused by UV light.
12 citations,
October 2016 in “Current opinion in genetics & development” Organs like hair follicles can renew themselves in complex ways, adapting to different needs and environments.
7 citations,
January 2015 in “Current problems in dermatology” Hair loss can be caused by stress, infections, drugs, and various diseases, with treatment depending on accurate diagnosis.
4 citations,
December 2020 in “Biomedical Papers/Biomedical Papers of the Faculty of Medicine of Palacký University, Olomouc Czech Republic” CD2 might be a new treatment target for patchy alopecia areata.
4 citations,
August 2014 in “Journal of Investigative Dermatology” Old people have less hair because their hair follicles don't regenerate as well, not because of fewer stem cells, and a protein called follistatin might help reactivate hair growth.
December 2022 in “bioRxiv (Cold Spring Harbor Laboratory)” MicroRNA-205 helps hair grow by changing the stiffness and contraction of hair follicle cells.
January 2018 in “Stem cells in clinical applications” Exosomes show promise for tissue repair and regeneration with advantages over traditional cell therapies.
7 citations,
January 2019 in “PeerJ” A protein called sFRP4 can slow down hair regrowth.
58 citations,
August 2015 in “The Indonesian Biomedical Journal” Different types of stem cells help maintain and heal skin.
4 citations,
November 2021 in “Frontiers in Cell and Developmental Biology” Aging causes hair loss and graying due to stem cell decline and changes in cell behavior and communication.
May 2024 in “Journal of Advanced Research” Communication between blood vessel and hair follicle cells decreases with age, affecting hair growth and blood vessel formation.
426 citations,
August 2014 in “Nature Medicine” Skin stem cells interacting with their environment is crucial for maintaining and regenerating skin and hair, and understanding this can help develop new treatments for skin and hair disorders.