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The study created a model to help design new inhibitors for steroidal 5α-reductase enzymes.

Researchers developed a model to predict how well certain compounds can block an enzyme related to hair loss and prostate issues, suggesting a 50 mg dose of finasteride might be effective based on lab and body data.

The method accurately measures testosterone metabolites with high sensitivity and low environmental impact.

New genes and pathways are important for testosterone production and male sexual development.

Human enzymes can detoxify harmful substances but might also increase their cancer risk.

Finasteride can cause one-sided breast enlargement, which disappears after stopping the drug.

Probe detects finasteride with high selectivity and low detection limit.

Curcumin and its derivatives can block an enzyme important for making testosterone, with one derivative being particularly strong.

Finasteride exposure harms tadpole reproduction and hormone balance.

Understanding how androgens work is key for creating new treatments for prostate issues and hair/skin conditions.

Genetic defects in testosterone production can cause hormonal and developmental disorders, and more research is needed to understand androgen regulation and develop safer treatments.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Male and female bodies respond differently to stress, influenced by hormones and development stages, with implications for stress-related diseases.

Estrogen replacement can improve skin health in menopausal women but doesn't reverse sun damage or prevent hair loss.

The human type II 5α-reductase gene, linked to certain male health conditions, has a specific structure and low similarity to other related genes.

The human type II 5α-reductase gene has a specific structure important for understanding certain medical conditions.

Understanding how hair follicle stem cells work can help find new ways to prevent hair loss and promote hair growth.

Environmental factors at different levels control hair stem cell activity, which could lead to new hair growth and alopecia treatments.

SHBG may be a useful early indicator and treatment target for PCOS.

Dihydrotestosterone increases the activity of an enzyme in pubic skin cells that converts testosterone to dihydrotestosterone.

Finasteride affects alcohol intake in male mice, possibly due to neurosteroids.

Selective non-steroidal inhibitors of 5α-reductase type 1 can help treat DHT-related disorders.

5α-reductase inhibitors, like finasteride and dutasteride, effectively treat BPH, male baldness, and hirsutism, with potential for acne and prostate cancer prevention.

Gonadal dysgenesis, like Turner's and Klinefelter's syndromes, negatively affects bone health, but hormone treatments can help.

Androgens like testosterone are important hormones for both men and women, made differently in each sex and affecting the body by regulating genes and quick interactions with cell components.

Not enough vitamin B6 in pregnant rats' diets caused poor development and health in their babies.

A boy with chromosome 13q deletion syndrome developed eye cancer, a woman with breast cancer lost vision due to a rare side-effect of her treatment, a man's vision worsened after using a hair loss drug, and two rare disorders were discussed. Optical Coherence Tomography is useful for diagnosing and monitoring these conditions.

Newer low-dose oral contraceptives with less androgenic effects improve patient compliance.

Eye exams are crucial for kids with 13q deletion syndrome, tamoxifen can cause vision loss, Propecia may lead to cataracts, Lipoid Proteinosis causes skin bumps, and OCT is useful for diagnosing macular diseases.

The new progesterone derivatives effectively inhibit 5α-reductase and bind to the androgen receptor.