Obstetric and Gynecologic Dermatology

The document presents a case study of a Hispanic woman who experienced the development of hyperpigmented, papillomatous confluent plaques in her axillae, neck, and areolae during the third month of her pregnancy. These skin changes worsened as the pregnancy progressed but began to fade after childbirth, with significant improvement by the fifth postpartum month. Laboratory tests excluded other syndromes, polycystic ovarian disease, and malignancy, and a skin biopsy showed epidermal acanthosis and papillomatosis without significant melanocytic hyperplasia. The condition, identified as Acanthosis Nigricans (AN), had an unclear cause since the patient did not have obesity, malignancy, or diabetes, and the lesions resolved after pregnancy. The document suggests that increased serum estrogen levels during pregnancy might have contributed to the AN-like skin changes, especially in women with a predisposition to pigmentary abnormalities. Additionally, the document briefly mentions unrelated cases of arterial embolization from hyaluronic acid injection and occupational dermatitis in woodworkers.