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Testosterone replacement may help some postmenopausal women with symptoms like fatigue and low libido, but more research is needed to fully understand its effects.

The Wnt/β-catenin pathway helps tissue regeneration but can also cause fibrosis, and drugs that inhibit this pathway may aid in healing skin and heart tissues.

All-trans retinoic acid causes hair loss by increasing TGF-β2 in hair follicle cells.

The document concludes that early diagnosis and treatment of Congenital Adrenal Hyperplasia are crucial for preventing serious health issues and improving patient outcomes.

Women with PCOS may take longer to get pregnant but can have a normal family size, and should manage their overall health to reduce long-term health risks.

PCOS starts in adolescence with hormonal issues, leading to adult health problems, and early treatment is crucial.

Skin development in mammals is controlled by key proteins and signals from underlying cells, involving stem cells for maintenance and repair.

EGF and KGF signalling prevent hair follicle formation and promote skin cell development in mice.

Correcting nutrient deficiencies may help with hair loss, but the benefits of supplements without a deficiency are uncertain and could be harmful.

Some heart drugs show promise for other conditions, but more research is needed to confirm their effectiveness and safety.

S5αR inhibitors might help treat schizophrenia and other mental disorders but need more research.

Topical drugs and near-infrared light therapy show potential for treating alopecia.

PCOS affects women's health by increasing the risk of diabetes, heart disease, and reproductive issues.

Overexpressing the mineralocorticoid receptor in mouse skin causes skin thinning, early skin barrier development, eye issues, and hair loss.

Shampoos are designed to clean and improve hair and scalp health, with specific ingredients for different hair types and conditions.

The document concludes that for hair and feather growth, it's better to target the environment around stem cells than the cells themselves.

Coffee silverskin may be a beneficial and safe ingredient for cosmetics, offering hydration, firmness, and potential hair growth benefits.

Lymphocytes, especially CD8+ T cells, play a key role in causing alopecia areata, and targeting them may lead to new treatments.

Nanoparticles around 600-700 nm can effectively enter and stay in hair follicles for days, which may help in delivering drugs to specific cells.

Both mouse and rat models are effective for testing alopecia areata treatments.

Blocking Wnt signaling in young mice causes thymus shrinkage and cell loss, but recovery is possible when the block is removed.

Lifestyle changes and weight loss are key for treating PCOS-related metabolic issues and infertility, with various medications available for specific symptoms.

Impaired androgen production in 46,XY DSDs causes ambiguous genitalia and requires long-term care.

The document concludes that mouse models are crucial for studying hair biology and that all mutant mice may have hair growth abnormalities that require detailed analysis to identify.

Glutamine metabolism affects hair stem cell maintenance and their ability to change back to stem cells.

Prolactin may play a significant role in skin and hair health and could be a target for treating skin and hair disorders.

The drug enzalutamide may reduce the ability of the virus causing COVID-19 to enter lung cells.

Cannabinoids may help treat chronic and chemotherapy-induced neuropathic pain, but more research is needed to confirm their effectiveness and safety.

Wnt10b helps blood stem cells grow after injury.

Polycystic Ovary Syndrome is common but often undiagnosed, and early treatment is important to prevent health problems.