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In this study, inducible whole-body Acly-knockout mice revealed that ACLY is essential for skin homeostasis, as its deficiency led to increased sebum production and skin abnormalities, indicating a vital role for cytosolic acetyl-CoA synthesis in preserving skin barrier integrity and systemic lipid regulation.

This narrative review synthesized current research on hormonal therapies in cosmetic dermatology, finding they offer promising, evidence-based applications for conditions like aging skin, acne, and melasma, but noting that safety and personalized treatment approaches are essential for responsible clinical use.

This article reviews assessment and management strategies for adolescent females with excessive hair growth and highlights the importance of evaluating potential androgen sources.

This review discusses the production, role, and measurement of dihydrotestosterone (DHT) in various disorders of sexual development but does not report new clinical results.

This review discusses the etiology, pathophysiology, trichoscopic characteristics, differential diagnoses, and treatment options for scalp seborrheic dermatitis, without providing new clinical findings.

This study demonstrated that adipose derived stem cells nanovesicles enhanced hair growth and reduced sebum secretion in androgenetic alopecia, showing effects comparable to minoxidil in laboratory and mouse models.

The researchers reported that nicotinic acid normalized excessive sebaceous lipogenesis without affecting basal lipogenesis and suggested potential anti-acne benefits.

This article outlines common and serious causes of excessive body hair in women, noting that benign conditions like polycystic ovarian syndrome are treatable, while dangerous causes require swift medical attention; it reports no new results.

This study found that acne was the most common dermatological manifestation in Korean women with polycystic ovary syndrome, particularly those with a specific combination of symptoms, showing distinct variations in serum hormonal and metabolic parameters.

In this study, the researchers found that constitutive activation of the EGFR in mice led to increased sebum production, enlarged sebaceous glands, and altered gene expression related to sebocyte proliferation and lipogenesis.

This review discusses the role of intrinsic skin signals, rather than serum signals, in regulating melanin synthesis and hair pigmentation, but reports no new experimental data.

This study observed that the osteopontin-derived peptide FOL-005 inhibited hair growth in human scalp skin models, contrary to its hair growth promotion in mice, supporting further clinical testing for excessive hair growth treatment.

This review discusses the similarities in clinical, endocrine, and ultrasonographic features between PCOS and other disorders with excessive androgen secretion, emphasizing the importance of accurate diagnosis but reports no new clinical results.

In this study, laparoscopic ovarian diathermy with three to five punctures per ovary improved reproductive outcomes for women with clomiphene-resistant polycystic ovary syndrome, while more than six punctures may cause excessive ovarian damage.

This review highlights the increasing use of herbal cosmetics for maintaining healthy hair growth and preventing premature greying, influenced by rising living standards and interest in personal care.

This report describes an exceptionally rare adrenal neoplasm in a post-menopausal woman that exclusively secreted DHEA-S, with significant serum level reduction following adrenalectomy.

This study demonstrates that T-cell responses in extensive alopecia areata scalp may be aberrantly regulated, with reduced cytokine production but activated phenotype, providing insight into the disease's immune mechanisms.

This review discusses melatonin's potential in dermatology, highlighting its antioxidative, immunomodulatory, and DNA repair properties, but reports no new clinical results.

This research presents a comprehensive workflow for producing EMA-compliant autologous keratinocyte-based therapies for wound healing and explores miRNA-mediated regulations in human keratinocytes and adipose-derived mesenchymal stem cells.

The book discussed in this abstract is a comprehensive guide to hair analysis, detailing the latest methods and applications across various fields such as toxicology and drug monitoring, designed for both newcomers and experts in the field.

This review summarizes recent multidisciplinary advances in sebaceous gland research and highlights potential novel therapeutic strategies for skin diseases, but it reports no new clinical results.

This study found that the acyl-CoA binding protein is essential for the production of very long chain free fatty acids in the stratum corneum and maintaining normal epidermal barrier function in mice.

This study found that local androgen biosynthesis and metabolism in human sebaceous glands play a crucial role in sebum synthesis and secretion.

This review discusses the causes, clinical features, diagnostic approach, and treatment options for hirsutism in women, but reports no new findings.

Hormonal therapy is effective for treating acne in adult women, especially with signs of high androgen levels.

This article provides an endocrine perspective on evaluating and managing hirsutism but reports no new research findings.

This review discusses the embryology, structure, and function of sebaceous glands and their involvement in skin disorders but reports no novel findings.

In this study, researchers found that serum granulysin levels might serve as a novel marker for disease activity in acute alopecia areata, being significantly associated with broader bald skin areas, poorer prognosis, and co-existing allergic disorders.

In this study, HA-P5, a nanoparticle derived from peptide and polysaccharide conjugation, effectively reduced acne lesions and sebum production by inhibiting specific receptors in cells, without triggering unfavorable reactions compared to a commercial inhibitor, highlighting HA-P5's potential as a novel acne treatment.

This study investigated the effects of pathological α-synuclein on sebaceous gland cells in Parkinson's disease, finding that α-synuclein exposure altered cellular differentiation and lipid production, suggesting a potential link between α-synuclein and lipid dysregulation in the skin of PD patients.