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This study found that MPZL3 knockout mice showed reduced dermal white adipose tissue and increased sebocyte proliferation, suggesting a regulatory role for MPZL3 in lipid metabolism balance between adipocytes and sebocytes.

This study found that a low-dose oral contraceptive containing dienogest provides effective contraception, improves cycle stability, and may reduce excessive scalp and skin oiliness, with high user satisfaction.

This study highlights the importance of clearly differentiating between gender identity and biological sex in dermatology research to ensure respectful treatment of patients and improve study accuracy, especially considering skin disease disparities and the underrepresentation of transgender and nonbinary individuals.

This paper reviews the significance of androgen hormones in hair and skin conditions like alopecia, hirsutism, and acne, and reports no new clinical findings.

In this study, hirsute women treated with cyproterone acetate and ethinyloestradiol experienced significant reductions in sebum secretion and hair growth after several months.

This study found that oral contraceptives, particularly those combining ethinyl estradiol with progestins like drospirenone and cyproterone acetate, are effective in treating androgen-related skin conditions such as acne, hirsutism, and androgenetic alopecia by reducing excess androgens and sebum production.

This article reports no new data; it describes the role of sebum in influencing the skin microbiome and epithelial tissues and discusses its altered composition during transit through the sebaceous duct.

This review identifies excessive sebum, decreased elasticity, and increased hair follicle volume as key factors contributing to enlarged skin pores, emphasizing the need for individualized treatment based on underlying causes.

This study found that serum MIF levels were significantly higher in patients with extensive alopecia areata compared to those with mild alopecia areata and healthy individuals.

This review discusses the mechanisms of skin barrier impairment in acne vulgaris and suggests strategies for its repair but reports no new clinical results.

In this study, researchers reviewed recent literature to investigate the influence of childhood and adolescent obesity on acne development, noting that excess body fat may contribute to acne through hormonal changes, inflammation, and metabolic dysfunction.

This review discusses the roles of androgens and androgen receptor in skin diseases like acne and hirsutism, and highlights the promise of antiandrogen drugs, reporting no new clinical findings.

Skin changes can indicate hormonal imbalances and help diagnose endocrine disorders.

This study describes a functional disorder in the ovary, known as stromal hyperplasia, characterized by the proliferation of ovarian stroma and luteinization of stromal cells, which is linked to excessive androgen production and elevated testosterone levels.

This research observed that Backhousia citriodora leaf extract effectively reduced sebum production and improved sebum composition across different ethnicities, significantly decreasing skin oiliness and the likelihood of shiny skin when used in a cream applied twice daily for 28 days.

This review explains that dysregulated sebum secretion and composition contribute to acne and impaired skin barriers while highlighting factors like diet and hormones affecting sebaceous activity, and identifies novel molecular targets and model systems for future therapeutic developments.

In this study, researchers found that cosmetic formulations containing guaraná extract effectively controlled oiliness in oily skin and hair by reducing sebaceous gland activity and lipid content without compromising skin barrier function, making them promising for managing excessive sebum production.

This review examines the physiological role of androgen conjugates in cutaneous androgen metabolism and questions their association with hirsutism, without presenting new clinical findings.

This review discusses the importance of androgen production and metabolism in hyperandrogenism, the use of specific serum markers for diagnosis, and the need for improved assays for clinical testing, but reports no new results.

This study reports that once neoplastic causes are excluded, functional hirsutism can be effectively treated with low-dose dexamethasone, oral contraceptives, and spironolactone.

Androgens like testosterone affect skin health and can lead to conditions such as acne and hair loss, with various treatments available.

In this study, cross-sex hormone therapy affected hair growth patterns differently, with estrogen reducing hair growth in male-to-female transsexuals and testosterone increasing it in female-to-male transsexuals; however, male typical hair diameters were not fully reached in the latter group after 12 months.

This study introduced a novel nonsteroidal androgen receptor antagonist that effectively controls sebum production in the golden Syrian hamster ear model through targeted follicular delivery.

The T-zone on the face has more androgen receptors and produces more oil than the U-zone.

Among cultured sebocytes, this study found that bilobetin significantly inhibited lipid production induced by IGF-1, suggesting potential for use in acne treatment.

This study revealed that deficiency in the enzyme FA2H in mice affected sebaceous gland function, altered sebum composition, and caused cycling alopecia, highlighting FA2H's role in hair follicle homeostasis.

In this study, ozenoxacin was found to inhibit sebum production in insulin- and 5α-DHT-differentiated hamster sebocytes in a dose-dependent manner, suggesting potential benefits in acne management by combining antimicrobial activity against C. acnes with reduced sebum production.

This study observed that among individuals with scalp seborrhoea, the scalp showed higher sebum levels, lower hydration, and compromised barrier function compared to other areas, and that a single shampoo application containing piroctone olamine significantly reduced sebum and oxidative stress markers.

This case report describes a 69-year-old woman with hirsutism and elevated serum testosterone, where surgery resolved symptoms and serum testosterone, suggesting ovarian steroid cell tumor consideration in similar profiles.

In this study, researchers found no hypertrophy in axillary sweat glands of hyperhidrotic patients, with eccrine gland clear cells being the primary site of fluid transport and no evidence of apoeccrine glands.