Inhibition of Insulin-Like Growth Factor-1 Induced Sebum Production by Bilobetin in Cultured Human Sebocytes

January 2019 in “ Annals of Dermatology ”

Cong Wang, Yul-Lye Hwang, Xue Mei Li, Soo Jung Kim, Ming Zhu, Jeung‐Hoon Lee, Rihua Jiang, Chang Deok Kim

TLDR Bilobetin may help reduce acne by decreasing sebum production.

The study suggested that bilobetin had the potential to inhibit sebum production in cultured human sebocytes, indicating its applicability for acne treatment.

View this study on anndermatol.org →

Discuss this study in the Community →

Research cited in this study

5 / 5 results

research Beyond Acne: Current Aspects of Sebaceous Gland Biology and Function

97 citations , September 2016 in “Reviews in Endocrine and Metabolic Disorders”

The sebaceous gland has more roles than just producing sebum and contributing to acne, and new research could lead to better skin disease treatments.

research Sebocytes’ Makeup: Novel Mechanisms and Concepts in the Physiology of the Human Sebaceous Glands

58 citations , March 2011 in “Pflügers Archiv für die gesamte Physiologie des Menschen und der Tiere/Pflügers Archiv”

Hormones and signaling pathways control sebaceous gland function and could help treat acne.

research Acne-Associated Syndromes: Models for Better Understanding of Acne Pathogenesis

99 citations , December 2010 in “Journal of The European Academy of Dermatology and Venereology”

The document concludes that certain genetic mutations and dietary factors are involved in acne development, and treatments like isotretinoin and diet changes can help manage it.

research Role of Insulin, Insulin-Like Growth Factor-1, Hyperglycemic Food, and Milk Consumption in the Pathogenesis of Acne Vulgaris

200 citations , August 2009 in “Experimental dermatology”

Eating high-glycemic foods and drinking milk may worsen acne by increasing insulin and IGF-1 levels.

research Acne and Sebaceous Gland Function

463 citations , September 2004 in “Clinics in dermatology”

Effective acne treatments should reduce sebum, bacteria, and inflammation, with isotretinoin being the best for severe cases.