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Tight junctions are key for skin protection and controlling what gets absorbed or passes through the skin.

Humans lost body hair relatively recently in evolution.

Nanoparticles improve drug delivery through the skin but more research is needed on their long-term effects and skin penetration challenges.

Targeting the IL-23/IL-17 pathway effectively treats several inflammatory skin diseases.

Lupus affects the body and skin, causing joint pain and skin issues that can be treated with steroids and antimalarial drugs.

The drug IPI-926 is safe at 160 mg daily and may help treat certain tumors, especially basal cell carcinoma.

Exosomes could potentially enhance tissue repair and regeneration with lower rejection risk and easier production than live cell therapies.

Early detection and intensive treatment of diseases caused by Staphylococcus aureus toxins are crucial for reducing severe health effects.

Surgery is the main treatment for liver hydatidosis, but has risks; albendazole is the most effective drug but can have side effects.

Understanding how cells die in the skin is important for treating skin diseases and preventing hair loss.

South Asian women with PCOS are more likely to have metabolic issues and central obesity, and simple measures like waist size and blood pressure can help identify these risks early.

Inhibiting 5α-reductase can help reduce prostate cancer risk and improve treatment.

Treating psoriasis on the scalp, nails, and skin folds is challenging, often requiring systemic treatments for severe cases, with some success in topical and biologic treatments.

Restoring hair bulb immune privilege is crucial for managing alopecia areata.

Male hormones and their receptors play a key role in hair loss and skin health, with potential new treatments being explored.

New treatments for Alopecia Areata show promise but need to be more effective and affordable.

Prolactin affects hair growth and skin conditions, and could be a target for new skin disease treatments.

There are many treatments for permanent hair loss disorders, but their effectiveness varies and there's no clear best option.

Minoxidil effectively treats severe hypertension but may cause side effects, so careful monitoring is needed.

Ozone reacts more with unwashed hair, producing compounds due to scalp oils, which could lower ozone exposure but increase exposure to reaction products.

Alopecia areata is likely caused by a combination of genetic factors and immune system dysfunction, and may represent different diseases with various causes.

Cholesterol sulfate buildup due to a genetic mutation disrupts the skin barrier, leading to the scaling skin seen in X-linked ichthyosis.

Six new genetic regions linked to early hair loss also connect to Parkinson's disease and prostate cancer, possibly leading to new treatments.

Treatments for melanin disorders exist, but more effective options needed.

Effective hair loss treatment in women requires correct diagnosis and can include medications like minoxidil, antiandrogens, and treatments for underlying conditions like PCOS.

The treatment combining docetaxel, cisplatin, and 5-FU is feasible and effective for advanced head and neck cancer.

New treatments for male hypogonadism are effective and should be personalized.

The document concludes that accurate measurement of serum androgens is crucial for diagnosing hyperandrogenism.

A20 protein is crucial for normal skin and hair development.

Hair grays due to oxidative stress and fewer functioning melanocytes.