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    Glossary Estrogen Receptor Antagonist

    blocks estrogen from activating its cellular receptors

    An Estrogen Receptor Antagonist, also known as an Estrogen Blocker or ER Antagonist, is a substance that binds to estrogen receptors on cells and prevents estrogen from exerting its effects. This can be useful in treating conditions like hormone-sensitive cancers, such as certain types of breast cancer, by inhibiting the growth-promoting effects of estrogen on these cancer cells.

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    1. On the Effect of Estrogen Receptor Agonists and Antagonists on the Mouse Hair Follicle Cycle Journal of Investigative Dermatology · 1998 · 11 citations
    2. Failure of Topical Estrogen Receptor Agonists and Antagonists to Alter Murine Hair Follicle Cycling Journal of Investigative Dermatology · 1998 · 8 citations
    3. An estrogen receptor pathway regulates the telogen-anagen hair follicle transition and influences epidermal cell proliferation. Proceedings of the National Academy of Sciences of the United States of America · 1996 · 154 citations
    4. 17β-Estradiol and ICI-182780 regulate the hair follicle cycle in mice through an estrogen receptor-α pathway 2000 · 71 citations
    5. Polyamine Oxidase Expression Is Downregulated by 17β-Estradiol via Estrogen Receptor 2 in Human MCF-7 Breast Cancer Cells International Journal of Molecular Sciences · 2022 · 8 citations
    6. Hair Cycle Control by Estrogens: Catagen Induction via Estrogen Receptor (ER)-α Is Checked by ERβ Signaling Endocrinology · 2005 · 92 citations
    7. Estrogen Receptor α, but not Estrogen Receptor β, is Involved in the Regulation of the Hair Follicle Cycling as well as the Thickness of Epidermis in Male Mice Journal of Investigative Dermatology · 2002 · 72 citations
    8. Bisphenol-A antagonizes the rapidly modulating effect of DHT on spinogenesis and long-term potentiation of hippocampal neurons Chemosphere · 2017 · 10 citations
    9. Atherogenesis: Estrogen Induction of Polysialylated nCAM (PSA-nCAM) Blocks Monocyte Capture by Vascular Endothelial Cells ISGE series · 2019
    10. Fulvestrant, a new treatment option for advanced breast cancer: tolerability versus existing agents Annals of Oncology · 2005 · 67 citations
    11. 17β-estradiol Inhibits the Production of RANTES in Human Keratinocytes Journal of Investigative Dermatology · 2003 · 56 citations
    12. On Photo-Stability of Oxybenzone Journal of Investigative Dermatology · 1998 · 6 citations
    13. Steroid Hormones Elsevier eBooks · 2016 · 3 citations
    14. In Vitro Main Pathways of Steroid Action in Cultured Hair Follicle Cells: Vascular Approach Journal of Investigative Dermatology Symposium Proceedings · 1999 · 30 citations
    15. Trends in the Development of New Drugs for Treatment of Benign Prostatic Hyperplasia Current Medicinal Chemistry · 2006 · 14 citations
    16. Clinical Snippets Journal of Investigative Dermatology · 2004
    17. Treatment of androgen excess in females: Yesterday, today and tomorrow Gynecological Endocrinology · 1997 · 9 citations
    18. Treatment of androgenic disorders in women: acne, hirsutism, and alopecia Cleveland Clinic journal of medicine · 1990 · 19 citations
    19. An estrogen receptor pathwayregulates thetelogen-anagen hair follicle transition andinfluences epidermal cell proliferation (epidermis/estrogen/keratinocyte/differentiation/mesenchymal 1996
    20. Triclocarban, Triclosan, Bromochlorophene, Chlorophene, and Climbazole Effects on Nuclear Receptors: An <i>in Silico</i> and <i>in Vitro</i> Study Environmental health perspectives · 2020 · 29 citations
    21. Glucocorticoid and Sex Hormone Receptors: Clinical Implications and Therapeutic Relevance Dermatologic Clinics · 2007 · 4 citations
    22. Cellular actions of testosterone in vascular cells: Mechanism independent of aromatization to estradiol Steroids · 2012 · 55 citations
    23. Mechanism of action of bolandiol (19-nortestosterone-3β,17β-diol), a unique anabolic steroid with androgenic, estrogenic, and progestational activities 2009 · 11 citations
    24. &lt;i&gt;In-Vitro&lt;/i&gt; Effect of Sex Steroids on Mouse Melanoma (B16F10) Cell Growth CellBio · 2014 · 11 citations
    25. Hormone Blocking Anticancer Drugs 2015
    26. Acne and sebaceous gland function Clinics in dermatology · 2004 · 463 citations
    27. Neues aus der Haarforschung: Einfluss von Prolaktin, Retinoiden und Transforming Growth Factor-β auf das Haarwachstum Aktuelle Dermatologie · 2005 · 3 citations
    28. Topical Finasteride Therapy in Hirsutism Endocrine Practice · 2001 · 1 citations
    29. Androgen Receptor Antagonists (Antiandrogens) Structure-Activity Relationships Current Medicinal Chemistry · 2000 · 204 citations
    30. Polymorphisms of the Androgen Receptor Gene and the Estrogen Receptor β Gene Are Associated with Androgen Levels in Women1 The Journal of Clinical Endocrinology and Metabolism · 2001 · 93 citations