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Androgens and androgen receptors are important for metabolic health, affecting how the body uses glucose and fats through mitochondrial function.

17β-estradiol may help hair growth by increasing cannabinoid receptor type 1.

Antiandrogens like flutamide are effective in treating conditions like prostate cancer and hair loss, but there's a need for more potent versions. Understanding their structure can help develop better treatments.

A protein called CBP is found in prostate cancer and can increase the effectiveness of certain prostate cancer treatments.

African American men with prostate cancer have more androgen receptor mutations, which may lead to more aggressive cancer compared to Caucasian American men.

The nature of the side chain in RU 58841 derivatives greatly affects its AR affinity, with the N-(iodopropenyl) derivative 13 showing the highest AR binding affinity, suggesting its potential for developing high-affinity radioiodinated AR radioligands.

New treatments for prostate cancer are less toxic and show promise, but more research is needed to enhance their effectiveness and reduce side effects.

A new compound was created in 2010 that can control oil production when applied to the skin, and its effects are completely reversible after two weeks.

Longer CAG repeats in gene linked to more severe hair loss in females.

Clascoterone is a new, effective, and safe acne treatment without systemic side effects.

Certain genetic variants in the androgen receptor are linked to higher PSA levels, potentially affecting prostate cancer screening outcomes.

Prostate cancer cells can make their own androgens to activate the androgen receptor, and treatments like abiraterone may increase this ability, suggesting new therapies should target the entire steroid-making pathway.

Lampreys have a functional vitamin D receptor that may help detoxify harmful substances.

Finger length ratios are not linked to the number of specific gene repeats affecting testosterone sensitivity.

The mineralocorticoid receptor may play a role in skin and hair health and could be a new target for treating related disorders.

The review found no clear link between vitamin D receptor gene variations and polycystic ovary syndrome.

Allopregnanolone is needed for certain brain processing issues caused by D1 dopamine receptor activation.

Using polymeric micelles to deliver spironolactone topically could improve wound healing in skin affected by glucocorticoids.

Different substances that activate or block the androgen receptor can affect male development and treat conditions like prostate cancer.

Finasteride and CPA-EE2 equally reduce hirsutism, but affect hormone levels differently.

LPA3 is crucial for embryo implantation and links LPA to prostaglandin signaling.

Human keratinocytes do not naturally respond to androgens.

Male hormones can decrease the ability of immune cells to fight bacteria.

Menopause reduces skin collagen and elasticity, and while estrogen therapy can help, its risks require careful consideration.

Estrogen helps keep skin healthy and may make women look younger and more attractive.

Understanding how androgens and their receptors work can lead to improved treatments for skin diseases.

A 12-year-old boy with PAIS successfully developed male characteristics using high-dose testosterone and anastrozole.

Cancer rates are increasing in developed countries, with estrogen, aging, low vitamin D3, and HPV infection as common causes.

The document concludes that targeting 5α-reductase, the androgen receptor, and hair growth genes, along with using compounds with anti-androgenic properties, could lead to more effective hair loss treatments.

Androgens cause oil-producing skin cells with androgen receptors to mature and produce more oil.