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The K15 promoter effectively targets stem cells in the hair follicle bulge.

The skin's layers protect, sense, and regulate the body's internal balance, but can be prone to cancer.

This study found that micro-niches within hair follicles create heterogeneity among stem cells and transit-amplifying cells, leading to specialized progenitors that control tissue morphogenesis and regeneration.

Keratins are crucial for cell structure, growth, and disease risk.

This review summarizes recent advancements in follicular targeting for drug delivery via hair follicles and calls for pilot studies in humans to explore potential clinical applications.

This review discusses the role of intrinsic skin signals, rather than serum signals, in regulating melanin synthesis and hair pigmentation, but reports no new experimental data.

This study describes a system for generating hair follicles from dissociated cells in mice, suggesting that successful development requires a foundational epithelial platform.

This study found that loss of Apc due to K14-cre-mediated gene recombination in mice led to aberrant growth in ectodermally derived squamous epithelia, implicating its critical role in specifying epithelial cell fates during embryonic development.

This study found that the phenotype of Hedgehog/Gli-driven skin tumors in mice depends on the cell of origin, tissue context, and level of oncogenic signaling.

This study demonstrates that bioengineered salivary gland transplants can fully regenerate gland function, producing saliva and restoring normal swallowing in salivary gland-defective mice, offering potential for xerostomia treatment.

This review discusses the shared molecular and cellular processes in the early development stages of skin appendages like hair follicles, teeth, and mammary glands, reporting no new results.

This study found that manipulating Wnt signaling pathways in cutaneous wounds can induce skin structures resembling regeneration, suggesting a potential role for Wnt signals in restoring skin architecture during wound healing.

This review discusses the application of liposomes in dermatology, highlighting their therapeutic value for drug stabilization, skin penetration enhancement, and treatment of hair follicle-associated disorders, but reports no new clinical results.

This review discusses the dynamic, niche-driven regulation of stem cell states in tissue homeostasis and regeneration, focusing on epithelial stem cells in the mammalian skin, intestine, and lung, without providing new experimental results.

This review discusses the development and advances in studying trichogenic dermal cells for hair follicle morphogenesis, summarizing methods, bioassays, and molecular markers, but reports no new research findings.

This article reviews the similarities in early development processes of hair follicles, teeth, and mammary glands and reports no new experimental findings.

This article reviews the current status of oral retinoids in dermatology and reports no new clinical findings.

This chapter reviews the complexity of hair and wool follicle formation, emphasizing the importance of cytological studies to understand the relationship between cellular components.

This study found that red ginseng oil may enhance hair growth and protect skin from UV damage in mouse models by promoting regenerative processes and reducing inflammation.

This review discusses recent discoveries about the role of Eda and other TNF-related cytokines in skin appendage development and reports no new experimental results, highlighting developments since the last comprehensive summary in 2003.

This study found that synchronized signals in the microenvironment regulate stem cell lineage choices in hair follicles by influencing chromatin dynamics during regeneration.

This study found that TPA was significantly more effective than mezerein in inducing dark basal keratinocytes in mouse skin, which may be important in early tumor promotion stages.

This study found that Sonic Hedgehog secreted by hair follicle transit-amplifying cells is essential for dermal adipogenesis and hair follicle growth by acting on adipocyte precursors.

This review discusses the use of dermal regeneration templates for treating burn injuries and other wounds, highlighting their effectiveness in reducing scars and aiding in regenerative processes, but reports no new clinical results.

This review explores how androgens and growth hormone influence the development of terminal hairs and sebaceous glands, attributing variability in hirsutism and acne to differing genetic sensitivities to androgens, but reports no new experimental data.

This article reviews historical reports of skin changes, such as pseudoacanthosis nigricans, associated with cholesterol-lowering drugs like triparanol and nicotinic acid, but presents no new clinical findings.

This review discusses the role of keratins in maintaining epidermal structure and function and reports no new results; the authors emphasize the lack of rational therapies for skin disorders linked to keratin mutations.

This study identifies six novel keratin genes from the chromosome 17q21.2 region, suggesting their association with hair follicles, while all 27 keratin genes in the domain have been characterized transcriptionally.

Fibroblasts can be turned into melanocytes for potential skin treatments.

This paper discusses the role of Runx1 in epithelial biology and pathology, highlighting its dual function as a tumor promoter and suppressor in different contexts, and reports no new experimental findings.