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The skin's internal clock affects healing, cancer risk, aging, immunity, and hair growth, and disruptions can harm skin health.

Mutations in the NR3C1 gene cause a rare condition that affects hormone signaling and can lead to various symptoms, with dexamethasone as a treatment option.

Certain ESR1 gene variations may affect hormone levels and fat distribution in women with high male hormone levels.

Mutations in the glucocorticoid receptor gene cause reduced sensitivity to glucocorticoids and may lead to poor response to treatment.

Hidradenitis Suppurativa has genetic links, with certain gene mutations more common in patients and a third of cases having a family history.

Cells with active Wnt signaling are less likely to turn into cancer when exposed to a cancer-causing gene.

Newborn skin cells can change into wound-healing cells more easily than adult ones, which might explain why baby skin heals without scars. Understanding this could help treat chronic wounds and prevent scarring.

Sex hormones like estrogen and testosterone may affect COVID-19 severity differently in men and women, potentially influencing prevention and treatment strategies.

MicroRNA-148a is crucial for maintaining healthy skin and hair growth by affecting stem cell functions.

Significant progress was made in understanding PXE, but effective treatments are still needed.

5-alpha reductase inhibitors, like finasteride and dutasteride, may cause depression, but more research is needed to understand why.

Bio-pulsed stimulation increases production of beneficial vesicles from bird stem cells that improve skin and hair cell functions.

Hair proteins in preschool children and their mothers could indicate developmental changes and health status.

Sex hormones affect hair growth and loss, and treatments for related hair diseases include various medications, hair transplantation, and light therapy.

Key genes and pathways involved in thyroid eye disease were identified, aiding potential treatment and diagnosis.

The review concludes that innovations in regenerative medicine, tissue engineering, and developmental biology are essential for effective tissue repair and organ transplants.

Androgenetic alopecia in men is genetic and linked to health issues like obesity and heart disease, with treatments including minoxidil, finasteride, and hair transplants.

The zinc finger protein 3 in Arabidopsis thaliana reduces plant growth and root hair development.

CXXC5 is a protein that controls cell growth and healing processes, and changes in its activity can lead to diseases like cancer and hair loss.

ASH2L is essential for skin and hair development.

Chromosomal differences affect how muscle cells respond to testosterone.

Human hair follicle stem cells can be turned into red blood cells.

Activating TLR3 improves the healing and immune properties of periodontal ligament stem cells.

Ectoin helps prevent cortisone-induced skin problems and supports skin health.

Ectodysplasin inhibits Wnt signaling to help form hair follicles.

Runx1 affects hair growth, cancer development, and autoimmune diseases in epithelial tissues.

Combining specific inducers helps dermal papilla cells regain hair-forming ability.

The document concludes that DNA methylation and the mTOR pathway are important for stem cell function and could impact disease treatment.

LPA3 signaling in the uterus is crucial for placental formation and fetal development.

Metabolism plays a key role in determining stem cell fate.