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    Glossary Enzalutamide

    blocks male hormones to treat prostate cancer

    Enzalutamide, also known by the brand name Xtandi, is a medication used to treat prostate cancer. It works by blocking the action of androgens (male hormones) that can promote the growth of cancer cells. This drug is particularly used in cases where the cancer has spread to other parts of the body and is resistant to other treatments.

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    Research 30 of 132

    1. The antiandrogen enzalutamide downregulates TMPRSS2 and reduces cellular entry of SARS-CoV-2 in human lung cells Nature Communications · 2021 · 50 citations
    2. TMPRSS2, required for SARS-CoV-2 entry, is downregulated in lung cells by enzalutamide, a prostate cancer therapeutic Research Square (Research Square) · 2020 · 2 citations
    3. Enzalutamide, a prostate cancer therapeutic, downregulates TMPRSS2 in lung and reduces cellular entry of SARS-CoV-2 Research Square (Research Square) · 2021 · 1 citations
    4. Enzalutamide/finasteride/goserelin/zoledronic-acid Reactions Weekly · 2024
    5. Androgenic Effects on Ventricular Repolarization Circulation · 2019 · 64 citations
    6. Redefining hormone resistance in prostate cancer Therapeutic Advances in Medical Oncology · 2009 · 38 citations
    7. Recent discoveries and developments of androgen receptor based therapy for prostate cancer MedChemComm · 2015 · 17 citations
    8. Androgen Receptor in Human Health: A Potential Therapeutic Target Current Drug Targets · 2012 · 12 citations
    9. Global Trends in Research of Androgen Receptor Associated With Breast Cancer From 2011 to 2020: A Scientometric Analysis Frontiers in Endocrinology · 2022 · 5 citations
    10. Cortexolone 17α-Propionate (Clascoterone) is an Androgen Receptor Antagonist in Dermal Papilla Cells In Vitro PubMed · 2019 · 4 citations
    11. Restricted effects of androgens on glucocorticoid signaling in the mouse prefrontal cortex and midbrain Frontiers in Endocrinology · 2024 · 3 citations
    12. Androgen Receptor Blockade Induces the Phagocytosis of MRSA and Pseudomonas aeruginosa by Monocyte-Derived Macrophages In Vitro Deleted Journal · 2025
    13. Synthesis and application of clinically approved small-molecule drugs targeting androgen receptor Bioorganic Chemistry · 2023
    14. Anogenital distance as a biomarker for incomplete masculinization : Molecular mechanisms in the perineum Research Portal Denmark · 2020
    15. P6590Androgenic effects on ventricular repolarization: a translational study from pharmacovigilance databases to iPSC-cardiomyocytes European heart journal · 2019
    16. Antiandrogens CRC Press eBooks · 2022
    17. Myricetin: A Significant Emphasis on Its Anticancer Potential via the Modulation of Inflammation and Signal Transduction Pathways International Journal of Molecular Sciences · 2023 · 54 citations
    18. A preliminary observation: Male pattern hair loss among hospitalized COVID‐19 patients in Spain – A potential clue to the role of androgens in COVID‐19 severity Journal of Cosmetic Dermatology · 2020 · 134 citations
    19. Alopecia With Endocrine Therapies in Patients With Cancer Oncologist · 2013 · 48 citations
    20. Androgen receptor modulators: a review of recent patents and reports (2012-2018) Expert Opinion on Therapeutic Patents · 2019 · 23 citations
    21. Computational Evaluation of Dibenzo Compounds as Potential Dual Inhibitors of Androgen Receptor and 5α-Reductase Asian journal of Current Research in Clinical Cancer · 2022
    22. Sex differences in COVID-19: the role of androgens in disease severity and progression Endocrine · 2020 · 121 citations
    23. Inhibition of SARS-CoV-2 entry through the ACE2/TMPRSS2 pathway: a promising approach for uncovering early COVID-19 drug therapies European Journal of Clinical Pharmacology · 2020 · 77 citations
    24. Vitamin D and androgen receptor-targeted therapy for triple-negative breast cancer Breast Cancer Research and Treatment · 2016 · 59 citations
    25. Steroidal 5α-reductase and 17α-hydroxylase/17,20-lyase (CYP17) inhibitors useful in the treatment of prostatic diseases The Journal of Steroid Biochemistry and Molecular Biology · 2013 · 51 citations
    26. Are sex discordant outcomes in COVID-19 related to sex hormones? Seminars in Oncology · 2020 · 42 citations
    27. Combined Oral Contraception and Bicalutamide in Polycystic Ovary Syndrome and Severe Hirsutism: A Double-Blind Randomized Controlled Trial The Journal of Clinical Endocrinology & Metabolism · 2017 · 25 citations
    28. Androgen Receptor Mutations and Polymorphisms in African American Prostate Cancer International Journal of Biological Sciences · 2014 · 23 citations
    29. Expression of concern: potential risk for developing severe COVID-19 disease among anabolic steroid users BMJ case reports · 2021 · 21 citations
    30. Testosterone target therapy: focus on immune response, controversies and clinical implications in patients with COVID-19 infection Therapeutic Advances in Endocrinology and Metabolism · 2021 · 21 citations