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This review discusses the structure, expression, regulation, and potential functions of the nuclear receptor coactivator NcoA4 in cancerous and non-cancerous pathologies, but reports no new results.

This study found that microneedles co-delivering minoxidil and a nitric oxide donor effectively promoted hair growth and follicle transition to the growth phase in an alopecia mouse model, suggesting a promising new approach for androgenetic alopecia treatment.

This case study highlights the overlooked condition of opioid-induced adrenal insufficiency, emphasizing the need for increased clinician awareness of its potential prevalence in chronic opioid users.

This study found that a novel proniosomal gel formulation of CoQ10 improved antioxidant levels and provided better skin protection against UV radiation compared to a conventional CoQ10 gel in animal models.

This study found that while 11-oxyandrogens do not aid in diagnosing PCOS, they correlate with hirsutism severity, and 11-ketotestosterone levels decrease with combined oral contraceptive therapy.

This study found that androgenetic alopecia treatments, especially dutasteride, are associated with a small increased risk of adverse events like sexual dysfunction and dermatologic reactions.

This study found that the K6/ODC transgenic mouse model is highly sensitive to identifying genotoxic carcinogens, showing 100% concordance with traditional rodent bioassays.

This review discusses the consensus reached by international experts on guidelines for prescribing and monitoring low-dose oral minoxidil for hair loss, and reports no new clinical results.

In this study, Alox15 knockout mice exhibited disrupted skin integrity and increased inflammation, suggesting that Alox15-mediated resolvin D2 production is crucial for maintaining skin homeostasis by suppressing inflammation.

This review summarized and classified 32 approved synthetic and natural-identical antioxidants, examining their regulatory status, safety, pharmacological properties, and effectiveness on human health, aiming to clarify their antioxidant actions and encourage further research in the field.

This study found a significant negative correlation between adrenal hormone DHEAS levels and ovarian volume in Greek women with polycystic ovary syndrome, though further clinical research is needed to confirm these results.

This study found that the transcription factor Lhx2 regulates Sonic Hedgehog signaling in mouse retinal progenitor cells, mainly by controlling the expression of co-receptors essential for effective pathway activation during early retinal neurogenesis.

This article discusses the use of low-dose oral minoxidil as an off-label treatment for androgenetic alopecia but reports no new clinical results.

This review discusses diosgenin's potential benefits for several chronic diseases and emphasizes extraction and quantification techniques, but reports no clinical findings.

This study found that during amelogenesis in Msx2 null mice, a dysfunctional enamel organ developed due to abnormal epithelial transformation and lacked proper enamel formation.

This research found that long-term use of minoxidil may rarely be associated with side effects unrelated to its known mechanism, though such effects are not well understood.

This study synthesized nonsteroidal ligands as second-generation androgen receptor agonists and identified three compounds with significant anabolic activity and moderate to minimal androgenic activity in vivo.

This study found an association between hydroxyl radical-modified SOD and alopecia areata, suggesting these modifications may lead to antibody induction in the condition.

This study reports the discovery of LX-38, a novel non-steroidal drug candidate that may offer safer treatment for conditions like Benign Prostatic Hyperplasia by avoiding hormonal side effects associated with current therapies.

This study reported that among US Spanish speakers with limited English proficiency, online searches for dermatological information most frequently focused on "pigmentation/dark spots" and "hair loss," with "pigmentation/dark spots" being the most common search term from 2010 to 2020.

This study found that Adapalene, Diosmin, and Azelastine have potential as multi-target drugs against Onchocerca volvulus and its endosymbiont, which might offer new therapeutic options for treating river blindness, but further research is needed to confirm their effectiveness.

This article reviews the use of hydralazine, minoxidil, and sodium nitroprusside in managing hypertension and hypertensive crises, noting specific indications, adverse effects, and the adjunctive therapies needed to mitigate side effects.

This study reported that the Computational Analysis of Novel Drug Opportunities platform effectively uses integrated biological data, including side effects and pathways, to generate potential drug candidates for colon cancer and migraine disorders.

This study found that multiple treatment regimens for refractory hypertension were effective in controlling blood pressure in most patients, with diazoxide being the most effective but least tolerable option.

This study found that introducing rat ornithine transcarbamylase gene into spf-ash mice improved liver and intestinal enzyme activity and normalized some metabolic indicators.

This study found that testosterone more accurately predicts PCOS diagnosis than 11-oxyandrogens, which were linked with hirsutism severity and showed varying responses to contraceptive and metformin treatments.

In this study, oral minoxidil combined with other medications improved blood pressure control in patients with severe hypertension but often had to be discontinued due to side effects.

This study found that spironolactone reduced fish fecundity and caused masculinization of females at certain concentrations, while having no effect on Daphnia magna reproduction, underscoring concerns for environmental exposure to vertebrates.