11-Oxyandrogen Concentrations in Adolescents With Polycystic Ovary Syndrome

    May 2021 in “ Journal of the Endocrine Society ”
    Anya Taylor, Meredith A Ware, Emily Breslow, Laura Pyle, Cameron Severn, Christine L. Chan, Megan M. Kelsey, Melanie Cree‐Green
    TLDR Adolescents with PCOS have higher levels of certain androgens, which are linked to hair growth but don't help diagnose PCOS better than testosterone levels.
    The study, conducted on 186 adolescent females aged 12-21 years, investigated the role of 11-oxyandrogens in Polycystic Ovary Syndrome (PCOS). The researchers found that untreated PCOS girls had higher 11-hydroxyandrostenedione (11OHA) and 11-hydroxytestosterone (11OHT) compared to controls, but these metabolites did not better predict PCOS status compared to testosterone. All three 11-oxyandrogens correlated with hirsutism severity. Combined oral contraceptive pill (COCP) treatment decreased 11-ketotestosterone (11KT) concentrations and total testosterone, while metformin treatment had no effect on 11-oxyandrogens but lowered total testosterone. The study concluded that while 11-oxyandrogens would not aid in the diagnosis of PCOS, they relate to excess hair growth and 11KT decreases with COCP therapy. Further research was suggested to determine the relationship with metabolic outcomes and the clinical utility of measuring these androgens in PCOS.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 1000+ results

      community 11 month Hairloss Journey- Goated Comeback?

      in Update  411 upvotes 2 weeks ago
      The user experienced significant hair regrowth after switching to oral finasteride and minoxidil in February 2025. They plan to stop using topical minoxidil gradually and have not experienced significant side effects from the treatment.

      community 11 Months Post-op , 5100 Grafts

      in Is this regrowth?  1249 upvotes 1 month ago
      A user shared their hair transplant experience with 5,100 grafts at Hair of Istanbul, costing $4,500, but many commenters suspect the post is promotional for the clinic. The user did not use Minoxidil or Finasteride post-surgery, which some commenters criticized.

      community 11 months of hair restoration progress and constant joy!

      in Progress Pictures  111 upvotes 4 months ago
      The post discusses an individual's 11-month hair restoration journey using oral finasteride, topical minoxidil and finasteride, micro-needling, biotin tablets, and ketoconazole shampoo. Despite mixed reactions and skepticism from others, the individual expresses gratitude for support and claims progress in hair growth.

      community 11 months Topical Min: Before and After (Ecstatic)

      in Progress Pictures  459 upvotes 5 months ago
      A 33-year-old woman shared her successful hair regrowth journey using topical Minoxidil 5% once daily, resulting in thicker hair and increased confidence. She avoided oral treatments like finasteride due to potential side effects and focused on consistent application of Minoxidil.

      community 11 years of finasteride usage 1 mg a day

      in Finasteride/Dutasteride  419 upvotes 6 months ago
      A user shared their 11-year experience with finasteride, noting temporary increased shedding that stopped, and advised continuing the treatment despite seasonal shedding. They reported no side effects and maintained a full head of hair.

    Related Research

    2 / 2 results