Dehydroepiandrosterone Sulfate, Insulin Resistance, and Ovarian Volume Assessment in Greek Women with Polycystic Ovary Syndrome (PCOS)

This study investigated the relationship between dehydroepiandrosterone sulfate (DHEA-S), insulin resistance, and ovarian volume in Greek women with polycystic ovary syndrome (PCOS). It included 321 women aged 17-35 who met the NIH 1990 and Rotterdam 2003 criteria for PCOS. The results showed a significant negative correlation between DHEA-S levels and both the average and maximum ovarian volumes, even after adjusting for age and BMI. The findings suggested a clear negative association between DHEA-S and ovarian volume, but further clinical studies were needed to confirm these results, as existing evidence was limited to experimental animal models.