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In this study, researchers used a CRISPR-based method to correct mutations in the COL7A1 gene in stem cells from RDEB patients, restoring normal collagen expression in engineered skin grafts in mice.

This review examines the role of endothelial precursors and cellularized scaffolds in wound repair and revascularization for treating full thickness skin loss, but reports no new clinical results.

This article reviews microneedle technology as a transdermal drug delivery platform without presenting new clinical results, emphasizing its engineered microstructure arrays for enhanced penetration.

This study reported that a decellularized porcine amniotic membrane hydrogel can alleviate inflammation and promote tissue repair in a UVB-induced skin inflammation model, suggesting its potential as a regenerative treatment for photodamage-associated skin injuries.

In this perspective, recent advances in regenerative medicine, including bioartificial substitutes and engineered in vitro platforms, are reviewed for their potential to restore human hair follicles, highlighting new technologies like 3D printing, hair-on-a-chip models, and stem cell-derived organoids.

In this study, researchers demonstrated that using 3D spheroid formation and genetic modification significantly enhanced the hair-inducing capacity of human dermal papilla cells in engineered skin constructs.

This study reports that eccrine sweat glands in mice predominantly develop on the footpads, offering a reference for skin research involving genetically engineered mice.

In this study, oil body-bound oleosin-rhFGF-10 was more efficiently absorbed through the skin and enhanced wound healing and hair growth in mice, compared to prokaryotically-expressed rhFGF-10.

In this study, exosome-loaded hydrogels derived from skin precursor cells significantly improved wound healing in diabetic rats by enhancing angiogenesis, reducing inflammation, and promoting tissue repair.

This study found that a microneedle patch with recombinant collagen XVII significantly improved hair coverage, follicle density, and angiogenesis in an androgenic alopecia mouse model, showing potential as a novel therapeutic strategy alongside established treatments like minoxidil.

This review highlights the potential of bioengineered dermal scaffolds in tissue engineering to enhance wound healing by mimicking the dermal structure and supporting cellular processes, while also discussing recent advancements and challenges in scaffold technology.

New methods for growing skin cells can improve skin grafts by building blood vessels within them.

This review describes how the skin can form its own immune response through dermal tertiary lymphoid organs, which function independently of traditional lymph nodes, potentially offering new insights into skin health care and treatments.

This review examines the regeneration capabilities of skin, oesophagus, and oral mucosa, highlighting the oral mucosa's unique scarless healing properties and the potential of cell therapy to improve scar reduction in wound healing.

This study found that a bioorthogonal microneedle patch delivering AAV-aFGF effectively improved hair follicle regeneration and sustained hair growth in murine alopecia models compared to other methods.

This paper reviews potential animal models for studying hidradenitis suppurativa, specifically suggesting that certain mouse models with genetic mutations might be useful, but it reports no new experimental findings.

This study developed a composite hydrogel that delivered multiple proteins, enhancing skin wound healing by accelerating closure and promoting hair follicle regeneration.

In this study, FN-based fiber scaffolds designed using Rotary Jet-Spinning were shown to enhance wound healing and reduce scar formation in a mouse model, suggesting potential for regenerating healthy skin structure.

This review discusses recent advances in understanding Merkel cell carcinoma biology, including the development of genetically-engineered mouse models and potential therapeutic targets, but reports no new clinical results.

This review discusses developments in tissue engineering for burn wound coverage and reconstructive surgery, reporting no new results but highlighting the need for further research into clinical effectiveness.

This review discusses recent findings on hair follicle morphogenesis and regeneration, focusing on molecular signals and stem cells, and suggests that understanding these processes may aid in developing new strategies for wound healing.

This review explores the potential diagnostic and therapeutic applications of extracellular vesicles in treating various skin conditions but reports no new clinical study results.

This study found that the RADA-GHK and RADA-KGHK peptide hydrogels improved wound healing and cell growth without cytotoxicity, suggesting potential for use in skin regeneration.

This study found that Mdm2 is critical for limiting p53 activity to maintain normal stem cell function in mouse skin, with impacts on tissue homeostasis and aging.

This study found that TGFβ signaling is essential for keeping sebocytes undifferentiated by reducing lipid-related gene expression, using a novel human sebocyte culture model.

Regulatory T cells help prevent autoimmunity and have potential for treating autoimmune diseases.

In this study, re-activating SOX9 in adult epidermal stem cells led to a fate switch towards hair follicle stem cell identity, with altered chromatin dynamics and oncogenic activation, contributing insights into developmental processes and cancer pathways.

This study established methods to isolate, culture, and expand rat hair follicle stem cells, which showed good proliferation and could serve as a cell source for tissue-engineered applications.

This review highlights that exosomes are showing promise as therapeutic, prognostic, and diagnostic agents in dermatology, with clinical studies suggesting efficacy for skin aging, scarring, hair restoration, and inflammatory conditions, though challenges in standardization and regulation remain.

This thesis found that desmoplakin mutations in cardiocutaneous syndrome are linked to dose-dependent disease severity and identified mechanisms by which KLHL24 mutations cause cardiomyopathy, with rescue experiments successfully preventing this phenotype in patient-derived heart tissues.