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Finasteride blocks deoxycorticosterone's anticonvulsant effects in infant rats, but indomethacin doesn't.

GABAergic steroid precursors reduce ethanol withdrawal symptoms in certain mice.

This study found that low androgen levels in rat penile endothelial cells were associated with a decrease in eNOS-expressing extracellular vesicles and reduced nitric oxide production.

This study found that chronic exposure to and withdrawal of progesterone influenced the expression and function of GABA A receptors in rat hippocampal neurons through its metabolite 3α,5α‐THPROG.

This study suggests that IV delivery of ExoFlo may be a safe and effective treatment for addressing symptoms in CRPS patients, warranting further investigation.

This study suggests that targeting adenosine receptors could be an effective strategy for reducing inflammation in inflammatory skin disorders, with promising results observed in animal models.

This study found that ethanol-induced deficits in motor coordination in rats are not mediated by elevated neuroactive steroid biosynthesis.

This study found that palmitoylethanolamide may stimulate allopregnanolone synthesis and reduce oxidative stress in astrocytes through PPAR-α activation, suggesting a neuroprotective role.

This study found that epitestosterone acts as a weak antiandrogen by inhibiting receptor binding and 5α-reductase activity in animal models.

This study found that a eupafolin nanoparticle delivery system improved water solubility and skin penetration, enhancing its antioxidant and anti-inflammatory effects against particulate matter-induced stress in skin cells.

This study found that the extract of Bidens pilosa L. improved dry eye symptoms associated with androgen deficiency in rats by enhancing tear production, stabilizing the tear film, and reducing lacrimal gland inflammation.

This study found that cortisol increases mac25/IGFBP-rP1 expression in osteoblast-enriched cells from fetal rat calvariae, indicating transcriptional regulation which may influence IGF and insulin effects in bone.

This review discusses the multifaceted roles of neurotrophins, especially nerve growth factor (NGF), in the development and function of nociceptors and reports no new clinical results.

In this study, pregnenolone was found to dose-dependently reduce L-DOPA-induced dyskinesias in a rat model of Parkinson's disease, suggesting its potential as a therapeutic target for these dyskinesias.

In this study, ethanol was found to enhance GABAergic neurosteroid production and inhibit long-term potentiation in rat hippocampal slices via unblocked NMDA receptor activation, effects reversible by specific inhibitors.

Certain peptides can prevent hair loss in young rats caused by a cancer drug.

This study found that blocking the hypothalamic-pituitary-gonadal axis in male rats reduced baroreflex dysfunction and inflammation caused by endotoxemia, highlighting potential therapeutic benefits.

This study discusses potential anti-inflammatory roles of endocannabinoid system modulation and phytocannabinoids in skin health, but reports no new clinical results; the authors emphasize the need for further clinical exploration.

People with an imbalance between their cognitive and emotional empathy have lower levels of the hormone oxytocin in their hair.

This study found that disrupting testosterone biosynthesis in male rats mitigated cardiovascular and autonomic impairments caused by endotoxemia, indicating testosterone's significant role in these conditions.

In this study, paroxetine's antihyperalgesic effect in a rat model of neuropathic pain was shown to be mediated by increased levels of the neurosteroid allopregnanolone in the spine.

Higher 3α,5α-THP levels in the brain may reduce depression in pregnant rats.

This study found that using elastic nano-liposomes to deliver palmitoylethanolamide improved its transdermal delivery and enhanced its skincare effects, with minimal cytotoxicity and no allergic reactions observed.

Allopregnanolone, a progesterone metabolite, helps reduce restraint effects on behavior.

In this study, adolescents with depressive symptoms were found to have higher urinary excretion rates of certain steroid metabolites, including corticosterone and adrenal hormones, and a specific metabolite ratio was identified as a potential biomarker for distinguishing these patients from healthy controls.

Lowering 3α,5α-THP in the hippocampus increases anxiety and depression in proestrous rats.

This study found that dracorhodin perchlorate improved wound healing in diabetic rats by regulating the TLR4 pathway and related inflammatory factors.

This study found that a 50% ethanolic extract of Adiantum capillus had significant analgesic and anti-inflammatory effects in animals, particularly at the highest tested dose of 300 mg/kg.

This study found that endothelin produced by hair follicle progenitors activates contractions in dermal sheath cells, facilitating hair follicle regression in the growth cycle.

This study found that blocking neurosteroid synthesis in pregnant sheep increased HPA axis activity, particularly under stress, suggesting neurosteroids help modulate stress response.