FPRL1 Receptor Agonist Peptides Prevent Etoposide-Induced Alopecia in Neonatal Rats

The study demonstrated that FPRL1 receptor agonist peptides, specifically MMK-1 and a mitochondrial peptide, effectively prevented etoposide-induced alopecia in neonatal rats. These peptides were administered intraperitoneally at a dose of 10 mg per kg for 4 days, starting 1 day before etoposide treatment, and were found to be more effective at lower doses compared to the previously studied fMLP. The anti-alopecia effects were linked to the involvement of histamine H1 and H2 receptors, as histamine antagonists blocked the protective effects of the peptides. This suggested that histamine release following FPRL1R agonist binding might play a role in preventing alopecia caused by anti-cancer drugs.