Antinociceptive Activity of Adiantum Capillus in Experimental Animals

The study from April 23, 2019, demonstrated that a 50% ethanolic extract of Adiantum capillus (ACE) has significant analgesic and anti-inflammatory effects in experimental animals. Administered at doses of 100, 200, and 300 mg/kg, ACE showed a dose-dependent increase in pain inhibition, with the 300 mg/kg dose being the most effective, reducing writhes by 54.56% in the acetic acid-induced writhing test and increasing reaction time on the hot plate. The extract also reduced carrageenan-induced paw edema in rats, suggesting anti-inflammatory properties. The study, which used 6 mice per group, concluded that ACE's effects might be due to the inhibition of prostaglandin synthesis and the presence of bioactive components such as rutin and quercetin. This suggests ACE could be beneficial for managing pain and inflammatory disorders.