March 2026 in “Scientific Reports” This study found that Cnidium officinale extract and its compound ferulic acid improved hair growth by promoting dermal papilla cell function and mitochondrial activity, suggesting their potential as a new treatment option for alopecia, possibly through estrogen receptor alpha activation.
March 2024 in “SVU- International Journal of Veterinary Sciences” This study suggests that fecal microbiota transplantation was effective in reducing symptoms of feline hyperesthesia syndrome, with most cats showing clinical remission or improvement and no observed side effects.
28 citations
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September 1998 in “Journal of Investigative Dermatology” This study isolated and characterized two distinct types of caspase-like proteases from human epidermis, suggesting their involvement in keratinocyte differentiation and apoptosis processes.
January 2015 in “프로그램북(구 초록집)” This study found that 2.5 mg/day of oral finasteride was effective in improving hair density in women with female pattern hair loss, especially in those with early onset and longer treatment durations.
April 2018 in “Journal of Investigative Dermatology” This study found that elevated STAT5 levels are linked to improved hair-inducing capabilities in human dermal papilla cells, and reducing STAT5 impairs hair follicle induction.
January 2025 in “Open Life Sciences” This study observed that transgenic mice with overexpression of HE4 developed keratitis and severe corneal opacity, suggesting that HE4 may significantly influence keratopathy and inflammatory responses in the eye.
14 citations
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July 2012 in “Journal of the American Academy of Dermatology” This study found that topical tacalcitol improved roughness and scaling in erythromelanosis follicularis faciei et colli, although it was less effective for facial erythema.
May 2024 in “European Journal of Immunology” This review discusses the potential of targeting Coenzyme A metabolism to restore metabolic balance, reduce chronic inflammation, and enhance immune function, particularly by modulating Vitamin B5 pathways involved in Th17-mediated inflammation and CD8-dependent anti-tumor immunity.
January 2023 in “Zenodo (CERN European Organization for Nuclear Research)” This abstract discusses the FitSpresso weight loss supplement's potential benefits and mechanisms but provides no clinical research findings; it reports on its ingredients and consumer ratings instead.
2 citations
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December 2018 This study found that dermatoscopy can quickly and non-invasively detect facial vellus hair involvement in patients with alopecia frontal fibrosante, occurring frequently and associated with specific facial lesions.
February 2026 in “Toxicology Letters” This study used an in silico/in vitro approach to identify potential inhibitors of the enzyme SRD5A2, finding that the androgen receptor modulator MK-0773 is a moderate inhibitor, although it does not act as a covalent inhibitor like finasteride.
292 citations
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October 1985 in “The Journal of Cell Biology” This study observed that the expression of certain keratins during human epidermal development marks the tissue's commitment to stratification and keratinization processes.
252 citations
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March 1998 in “Developmental dynamics” This study suggests that fibroblast growth factors FGF-4, FGF-8, and FGF-9 may play redundant roles as signals in epithelial-mesenchymal interactions during multiple stages of tooth development in mice.
April 2017 in “Journal of Investigative Dermatology” In this study, HPH-15, a newly synthesized compound, demonstrated potential in reducing skin fibrosis in a mouse model by targeting underlying pathogenic mechanisms and exhibited a good safety profile, warranting further clinical trials for fibrotic skin disorders like systemic sclerosis.
9 citations
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January 1992 in “Journal of Investigative Dermatology” This study found distinct differences in UEA I glycoprotein binding on follicular keratinocytes between anagen and telogen hair follicles, with staining associated with follicle length and regrowth.
November 2023 in “Scientific reports” This study presents the first report on cloning and characterizing the full-length cDNA of SRD5A1 in Indian catfish (Clarias magur), revealing expression differences across reproductive phases and increased expression post-Ovatide administration in ovaries and testis.
This study concluded that the combination of all-trans-retinoic acid and tocopherol-α is not recommended for treating del(5q) myelodysplastic syndromes due to low efficacy and high incidence of adverse effects.
1 citations
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January 2025 in “Reproductive Biology and Endocrinology” This study suggests that supplementing with a cell-free fat extract might enhance embryo development and improve clinical outcomes in older women experiencing in vitro fertilization failure.
Activin A and Follistatin affect how mouse hair follicles grow.
4 citations
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July 2020 in “Research Square (Research Square)” This study provided the crystal structure of the human steroid 5α-reductase 2 enzyme and identified key molecular mechanisms for testosterone reduction and finasteride inhibition, aiding in understanding disease-causing mutations and potentially facilitating new drug development.
The document cannot be parsed, so there is no conclusion to summarize.
9 citations
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January 2020 in “Postepy Dermatologii I Alergologii” This review discusses the enigmatic nature of frontal fibrosing alopecia and reports no clinical results; the authors stress the need for further research.
August 2022 in “IntechOpen eBooks” This review discusses treatments for frontal fibrosing alopecia and lichen planopilaris, noting that systemic 5-alpha reductase inhibitors are most effective for stabilization and potential hair regrowth, but reports no new clinical results.
5 citations
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September 2019 in “The Open biomarkers journal” This study found that linoleic acid may help protect against acrylamide toxicity in female albino rats.
12 citations
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March 2021 in “Journal of Investigative Dermatology” TRPM5 is crucial for maintaining hair growth.
119 citations
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November 2014 in “Trends in Cell Biology” This review discusses the mechanisms and pathways of FGFR signalling and its roles in development, disorders, and therapeutic targeting, but reports no new clinical results.
March 1996 in “Hair transplant forum international” This article discusses the introduction and market presence of the Italian hair product Kevis but presents no new clinical findings.
35 citations
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October 2013 in “Journal of Dermatological Science” This study observed that VEGF165 increases proliferation and migration but alters adhesion properties of cultured human hair follicle cells, indicating a potential role for VEGF/VEGFR-2 in hair follicle regulation beyond angiogenesis.
22 citations
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April 2022 in “Stem cell research & therapy” This study found that extracellular vesicles derived from hair follicle mesenchymal stromal cells demonstrated similar potential to those from adipose tissue in promoting cell proliferation and migration, enhancing angiogenesis, and protecting cells under stress, suggesting promise for chronic wound treatment.
April 2024 in “The Journal of urology/The journal of urology” In this study, researchers found that methylation of the SRD5A2 gene in blood and tissue samples can serve as a biomarker to predict men's clinical response to finasteride treatment for benign prostatic hyperplasia, offering a non-invasive method for assessing potential treatment success.