Cell-Free Fat Extract Improves Embryo Development and Clinical Outcomes in Older Women with Previous In-Vitro Fertilization Failure

The study explored the impact of cell-free fat extract (CEFFE) on embryo development and clinical outcomes in older women with previous IVF failures. Involving 56 women aged ≥35 years, the study found that CEFFE, derived from human subcutaneous adipose tissue and rich in growth factors, improved embryo quality and pregnancy rates. In vitro experiments with mice showed that 2% CEFFE increased blastocyst cell numbers and reduced apoptosis. Human trials indicated improved day 3 embryo quality and higher implantation and clinical pregnancy rates. Despite its promising results, the study noted limitations and recommended further large-scale trials and long-term tracking before CEFFE's integration into personalized care programs.