Intradermal Local Injection of Autologous Cell-Free Fat Extract for the Treatment of Refractory Postinflammatory Hyperpigmentation

January 2023 in “ Dermatologic Therapy ”

Yizuo Cai, Zhuoxuan Jia, Jiancheng Gu, Bijun Kang, Hongjie Zheng, Wei Li, Wenjie Zhang

autologous cell-free fat extract postinflammatory hyperpigmentation intradermal injection transepidermal water loss skin lightness

TLDR CEFFE injections effectively and safely improve postinflammatory hyperpigmentation.

This study evaluated the efficacy and tolerability of autologous cell-free fat extract (CEFFE) for treating postinflammatory hyperpigmentation (PIH) in 15 patients. Participants received five intracutaneous CEFFE injections at two-week intervals. Results showed significant improvements in the brown spot index, transepidermal water loss, skin lightness, and lesion color at the 12-month follow-up (p < 0.05). Additionally, 93.33% of patients reported improved or greatly improved conditions. The treatment was well-tolerated, with only transient local bruising and stinging as adverse events. These findings suggest that CEFFE injections are an effective and safe treatment for PIH.

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