Intraovarian Vascular Enhancement via Stromal Injection of Platelet-Derived Growth Factors: Exploring Subsequent Oocyte Chromosomal Status and In Vitro Fertilization Outcomes

    May 2020 in “ Daehan saengsik uihak hoeji/Clinical and experimental reproductive medicine ”
    Samuel H. Wood, E. Scott Sills
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    TLDR Injecting platelet-derived growth factors into ovaries may improve IVF outcomes by enhancing egg quality and embryo health.
    The study explored the use of platelet-derived growth factors injected into ovarian tissue to enhance vascularity and improve outcomes in in vitro fertilization (IVF), particularly for older women facing challenges due to poor oocyte quality and chromosomal errors. The research suggested that the angiogenic properties of platelet-rich plasma (PRP) could improve follicular perfusion and oxygenation, potentially rescuing embryo ploidy by modulating oocyte competence. This approach aimed to reduce the need for donor oocytes and hormone replacement therapy by supporting intrastromal angiogenesis and improving reproductive outcomes through PRP-associated molecular signaling.
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