Regenerative Effect of Intraovarian Injection of Activated Autologous Platelet-Rich Plasma: Serum Anti-Mullerian Hormone Levels Measured Among Poor-Prognosis In Vitro Fertilization Patients

This clinical trial investigated the effects of intraovarian injection of activated autologous platelet rich plasma (PRP) on serum anti-Mullerian hormone (AMH) levels in 182 poor-prognosis IVF patients with low ovarian reserve. The study found that 28% of patients experienced a significant increase in AMH levels, with a median increase of 167% within four weeks post-treatment. The improvement was observed across different age groups, and responders had a higher mean basal platelet count compared to non-responders. The trial concluded that the PRP treatment was safe and effective for some patients, suggesting the need for further research to optimize PRP protocols and better understand ovarian response.