Preliminary Report of Intraovarian Injections of Autologous Platelet-Rich Plasma in Extremely Poor Prognosis Patients with Only Oocyte Donation as Alternative: A Prospective Cohort Study

    January 2022 in “ Human Reproduction Open ”
    David H. Barad, David F. Albertini, Emanuela Molinari, Norbert Gleicher
    TLDR PRP injections did not significantly improve ovarian function in women with low ovarian reserve.
    The study involved 80 women with extremely poor ovarian reserve and investigated the effects of intraovarian injections of autologous platelet-rich plasma (PRP) on fertility outcomes. Over a 1-year follow-up, the study found no clinically significant improvements in ovarian function, with only a 2.5% ongoing pregnancy rate and 2 women delivering healthy children. Although there was a statistically significant increase in antral follicle counts post-PRP, the overall impact on IVF outcomes was limited, with no significant improvement in the number of oocytes retrieved, embryo quality, or live birth rates. The study concluded that PRP should remain investigational, emphasizing the need for further controlled research to validate its efficacy and understand its potential benefits and limitations.
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