19 citations
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June 2008 in “Journal of Investigative Dermatology” This study found that transgenic mice with expression of HPV16 E6/E7 oncogenes showed improved ear tissue regeneration, including hair follicles and cartilage, without tumor formation.
19 citations
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July 1994 in “International Journal of Dermatology” This case report describes a 9-year-old Korean boy with a calcified nodule on his earlobe, confirmed by histopathologic examination and Von Kossa staining.
15 citations
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August 1988 in “Archives of Otolaryngology - Head and Neck Surgery” This paper reports a case of severe hypertrichosis in the external ear canal due to minoxidil use, leading to chronic otitis externa and hearing loss.
11 citations
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November 2009 in “Brazilian Journal of Medical and Biological Research” This study found that young C57BL/6 and BALB/c mice exhibit distinct regenerative patterns during ear wound healing, with greater wound closure but less regeneration in middle-aged C57BL/6 mice.
6 citations
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November 2022 in “Forensic Science Medicine and Pathology” This study demonstrated that genetic markers can predict human ear morphology with moderate to good accuracy, potentially aiding forensic identification in crime scene investigations where traditional DNA matches are unavailable.
3 citations
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February 2009 in “Chinese Journal of Traumatology (english Edition)” This study found that implanting microencapsulated dermal papilla cells in rat ears led to hair follicle regeneration, suggesting a potential alternative to fresh isolated dermal papillae for inducing hair growth.
This study found that a combination of four transcription factors can transform mouse fibroblasts into cells resembling inner ear hair cells, potentially aiding research into hearing loss treatments.
October 2025 in “The Sri Lanka Journal of Dermatology” This case report highlights the diagnostic challenge of inverted follicular keratosis, emphasizing the importance of histopathology for accurate differentiation from malignancies.
January 2015 in “Pathology” A 64-year-old man had a rare skin cancer near his ear, unresponsive to antibiotics, with specific skin and hair follicle changes.
This study found that Xiaochuang Drink significantly reduced the sebaceous gland and hair follicle diameter in a rabbit ear acne model and was determined to be safe at clinical doses.
January 2011 in “The Chinese Journal of Dermatovenereology” This study found that curcuma anti-acne gel reduced comedo formation and improved skin characteristics in a rabbit ear acne model, showing potential for treating acne.
January 2008 in “Journal of Practical Medical Techniques” This study found that microencapsulated dermal papillae cells induced hair follicle regeneration in rat ears, differing from normal follicles in configuration, size, number, and differentiation degree.
March 2006 in “Chinese journal of plastic surgery” This study found that microencapsulated dermal papilla cells implanted into mice ears led to the successful regeneration of hair follicles, with APA microencapsulations of 400µm diameter allowing effective nutrient exchange.
February 1990 in “Pathology, research and practice” This study in rats with a portocaval shunt observed severe ultrastructural damage to the inner ear, associated with zinc deficiency and symptoms resembling liver cirrhosis in humans.
Lichen planopilaris and frontal fibrosing alopecia are likely the same disease with different clinical appearances.
125 citations
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August 1992 in “Development” This study found that implanting isolated adult rat dermal papillae into ear cuts led to the emergence of unusually large vibrissa-type hair follicles, demonstrating their capacity to induce specific hair fiber characteristics.
110 citations
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January 2014 in “Journal of Controlled Release” Phospholipid-coated nanoparticles penetrate hair follicles better than others, especially in pig ears.
26 citations
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October 2023 in “Neuroscience Bulletin” In this review, the authors discuss how understanding and co-regulating multiple signaling pathways could lead to effective regeneration of functional hair cells, highlighting current achievements and future approaches such as small molecule drugs and gene therapy for treating sensorineural hearing loss.
13 citations
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November 1995 in “European Archives of Oto-Rhino-Laryngology” 8 citations
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April 2012 in “Laser Physics Letters” This study found that a curcumin-labeled particle-associated antiseptic penetrated deeper into hair follicles in porcine skin than particles without antiseptic.
5 citations
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November 2001 in “Auris Nasus Larynx” This case report presents a rare instance of Winer's dilated pore in a 51-year-old female, emphasizing its pathological features and the need for accurate differential diagnosis to avoid misinterpreting it for more serious conditions.
3 citations
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April 2015 in “International research journal of pharmacy” This study concluded that the follicular route is a significant pathway for delivering gentamicin through the skin, as demonstrated by higher drug permeation in non-plugged pig's ear skin compared to plugged skin.
September 2018 in “Plastic and reconstructive surgery. Global open” This study found that using conchal cartilage grafts to reinforce split earlobe repairs provided satisfactory aesthetic and functional outcomes, with no recurrence of tears over a 4-year follow-up.
98 citations
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July 1968 in “Archives of Dermatology” This study found that applying scalp sebum from young men to rabbit ear canals caused follicular hyperkeratosis, suggesting sebum stimulates the formation of comedones, a key feature in acne vulgaris.
25 citations
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April 2018 in “Electromagnetic biology and medicine” This study found that radiofrequency radiation from mobile phone use may increase DNA damage in hair follicle cells of the ear canal, with greater exposure duration linked to higher damage levels.
1 citations
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August 2023 in “Genome research” This study found that in spiny mice, the proximal side of ear wounds is crucial for regeneration, a process possibly linked to unique injury-induced immune responses compared to nonregenerative rodents.
September 2023 in “Journal of The American Academy of Dermatology” This study examined the clinicopathological characteristics of cutaneous squamous cell carcinoma on the scalp and ear but reported no new results on its association with androgenetic alopecia.
November 2024 in “Open Repository of the University of Porto (University of Porto)” This report details a six-month internship experience, split between hospital and community pharmacy settings, which enhanced practical skills and theoretical knowledge in pharmaceutical care and highlighted the pharmacist's role in ensuring safe medication use.
11 citations
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August 2010 in “Developmental neurobiology” This study suggests that Ptprq in the hair bundles may exist as multiple isoforms that are differentially expressed throughout development and affect the organization of stereocilia in the chick inner ear.
This study reported that rapamycin reduced murine cochlear organoid proliferation depending on concentration, but at a 10-nM dose, it significantly increased hair cell differentiation by enriching SOX2+ progenitors while suppressing cells lacking Sox2 at early proliferation stages.