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This article reviews the use of cross-sex hormonal therapy in transmen and reports that it is reasonably safe, suggesting monitoring should be frequent initially but can be less frequent over time.

This study identifies a likely pathogenic homozygous missense variant in the AEBP1 gene in a patient with symptoms of classical Ehlers-Danlos syndrome, suggesting new perspectives for EDS classification and research.

This review discusses the pathophysiology, diagnosis, and management of functional hypothalamic amenorrhea in adolescent girls and reports no new clinical results.

This review discusses metformin's use in women with polycystic ovary syndrome, focusing on benefits during pre-conception and pregnancy, but reports no new clinical results.

In this study, the ChatGPT-5 model accurately answered 76.47% of questions on the Polish endocrinology specialty exam, surpassing the 60% passing threshold, yet its role in clinical decision-making remains uncertain, highlighting the need for further research.

This study found that patients with juvenile-onset systemic lupus erythematosus have a high prevalence of endocrine and metabolic comorbidities, particularly dyslipidemia and obesity-related issues, suggesting the need for routine monitoring and obesity prevention.

This review examines complex regional pain syndrome (CRPS I) mechanisms, including immune dysregulation and psychological factors, but reports no new clinical results; the authors highlight potential diagnostic refinements.

In this study, researchers found that certain vitamin D receptor gene polymorphisms are significantly related to insulin concentration during a glucose tolerance test in young women with hyperandrogenism, but these polymorphisms did not affect bone metabolism or other biochemical parameters.

This study concluded that high-intensity interval training (HIIT) offers superior benefits over standard moderate-intensity continuous training (MICT) in improving aerobic capacity, insulin sensitivity, hormonal profiles, and anxiety scores in overweight women with PCOS.

This study introduces a modular fiber model to investigate how changes in microstructural properties of wool affect its critical buckling load, highlighting potential uses and areas needing further research in wool fiber biophysics.

This review discusses strategies for maintaining access to gender-affirming care for gender diverse youth during the COVID-19 pandemic and reports no new clinical results.

This report highlights that Klinefelter syndrome is often underdiagnosed due to phenotypic variability and emphasizes the importance of thorough physical examinations to improve diagnostic timing.

This case report describes ALP elevation in a patient with severe OA that normalized after bilateral knee replacements, highlighting a potential link between OA and ALP levels.

In this study, activation of Tgr5 was found to improve alopecia areata and bone microstructure in mice by down-regulating the JAK1-STAT3 signaling pathway.

This consensus statement discusses guidelines for screening, diagnosing, and treating the Female Athlete Triad, and introduces a risk stratification system to assist healthcare providers with sports participation decisions.

This study observed that among patients with Myhre syndrome, those with the SMAD4 gene variant p.Arg496Cys experienced fewer symptoms like hearing loss, while those with the p.Ile500Thr variant often had severe aortic hypoplasia, highlighting the diverse symptom progression and genetic factors of this rare condition.

This review highlights the possible impact of side effects from endocrine therapy on quality of life, emphasizing that these can lead to poor adherence and early treatment discontinuation in patients with hormone receptor positive early breast cancer, potentially worsening survival outcomes.

This review discusses the relationship between gut microbiota and polycystic ovarian syndrome (PCOS), including its potential mechanisms and the role of alterations in microbiome composition on PCOS pathophysiology.

In this case report from People's College of Medical Sciences, a 20-year-old man initially misdiagnosed with Addison's disease was ultimately found to have strongyloidiasis, with his symptoms and weight loss improving after antihelminthic treatment.

This source provides a comprehensive guideline for the management of transgender individuals in India, highlighting the need for multidisciplinary diagnosis, counseling for gender-affirming hormone therapy, and the importance of addressing social stigma, legal issues, and medical training to improve healthcare access for this population.

These guidelines recommend testing thyroid function in patients with obesity due to common hypothyroidism, and highlight that weight loss is crucial for addressing hormonal imbalances, with only modest weight loss benefits from treating endocrine disorders.

This study suggests that oral budesonide may not effectively maintain remission in Crohn's disease beyond three months, with minor benefits that are outweighed by increased rates of treatment-related adverse events.

This study found that mice lacking syndecan-1 experienced cold stress and metabolic issues due to reduced intradermal fat, which was restored by thermoneutral housing or rosiglitazone treatment.

In this study, researchers observed that graded calorie restriction in mice led to changes in stable isotope ratios and elemental content in bone collagen and hair keratin, potentially indicating intensified mobilization of endogenous proteins and altered bone collagen structure with increased dietary stress.

In this pilot randomized clinical trial, TRT combined with finasteride increased lean mass, muscle size, and bone mineral density without prostate enlargement in men with spinal cord injury, suggesting potential benefits for body composition and musculoskeletal health.

This narrative review suggests that, after at least two years of gender-affirming hormone therapy, nonathletic transgender individuals tend to have physical performance levels similar to cisgender individuals, though more controlled research is necessary, particularly among trans athletes.

This study found that 50% of patients with patchy alopecia areata who underwent chronic intralesional triamcinolone acetonide therapy had abnormal bone mineral density, suggesting the need for monitoring and preventive measures.

The authors concluded that diazoxide reduces undesirable side effects compared to minoxidil while increasing elastic fiber content and decreasing cell number in the aorta, suggesting potential suitability for treating vascular conditions with low arterial elastin and hypertension.

This study found that the combination of mammography and hair X-ray diffraction increased sensitivity for detecting breast cancer compared to using each method alone.

This study found that the TrichoScan method detected significant increases in hair counts and cumulative hair thickness in men after finasteride treatment, suggesting its potential for monitoring hair treatment responses.