12 citations
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September 2015 in “Drug Design Development and Therapy” This study found that the DOX derivative AD198 more effectively inhibited cell viability and induced apoptosis in canine cancer cell lines K9TCC and K9OSA compared to DOX in vitro.
17 citations
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October 2023 in “Molecules” In laboratory and artificial skin model experiments, this study found that plant-derived PDRN from Korean ginseng effectively promoted skin cell regeneration and strengthened the skin barrier, suggesting a sustainable alternative to animal-derived PDRN.
April 2016 in “Journal of Investigative Dermatology” This study found that Pdgfα signaling is crucial for maintaining dermal adipose tissue in mice by initiating dermal adipocyte stem cell proliferation, with implications for age-related skin defects.
40 citations
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July 2023 in “Clinical Pharmacology & Therapeutics” This review discusses the progress and challenges of targeted protein degradation therapies, highlighting the increasing number of degraders in cancer clinical trials and the limited diversity in targeted proteins, primarily focusing on those employing CRL4CRBN as the E3 ligase.
This study found that dermal papilla cell-derived exosomes may enhance hair follicle regeneration during wound healing by boosting fibroblast hair-inducing capacity and activating the Wnt/β-catenin signaling pathway.
March 2025 in “Journal of Cosmetic Dermatology” In this case study, a 29-year-old woman with Pseudopelade of Brocq, a type of scarring alopecia, showed significant hair density improvement following a combination of scalp reduction surgery and concentrated growth factor injections postoperatively, which addressed scar complications and inflammation.
June 2026 in “Oriental Journal Of Chemistry” This research found that a novel dehydroepiandrosterone derivative (12) significantly reduces cell viability and increases apoptosis in testosterone-stimulated normal and tumor prostate cells, unlike finasteride and dutasteride, which also showed activity under dihydrotestosterone stimulation.
August 2000 in “Chinese Journal of Dermatology” This study found that dermal papilla cells can induce and sustain hair follicle regeneration and growth in both laboratory and animal settings.
8 citations
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March 2015 in “Molecular Medicine Reports” This study found that para-phenylenediamine induces cytotoxic effects in normal human hair dermal papilla cells by altering microRNA expression and causing cell death, cell cycle arrest, and oxidative stress.
This study reported that dupilumab successfully induced remission of chronic, disseminated eczema herpeticum in a six-year-old girl with DOCK8-deficiency hyper-IgE syndrome, achieving complete resolution of herpetic lesions and significant skin, hair, and nail improvement within three months.
January 2026 in “Biomaterials”
2 citations
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August 2013 in “British Journal of Dermatology” This case report observed a dramatic improvement in a 15-year-old girl's pachyonychia congenita symptoms during chemotherapy for Ewing sarcoma, suggesting chemotherapy's potential role in managing hyperkeratotic conditions.
2 citations
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February 2015 in “Journal of Tissue Engineering and Regenerative Medicine” This study found that transplanting trichogenous dermal cells significantly enhanced the restoration of in vivo-damaged hair follicles in a nude rat model, with a combination of dermal papilla and sheath cells proving more effective than either cell type alone.
May 2023 in “Stem cell research & therapy” This study describes a novel method using force-triggered density gradient sedimentation for efficiently isolating dermal papilla cells from neonatal mouse skin, showing promise for hair follicle regeneration research.
3 citations
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December 1997 in “Pediatric Clinics of North America” This article reviews adolescent sexual behavior and emphasizes the importance of hormonal contraception for sexually active teenagers, suggesting that health care providers play a crucial role in addressing their reproductive needs.
9 citations
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September 2019 in “Clinical Cosmetic and Investigational Dermatology” In this article, the authors reported that calcipotriol/betamethasone dipropionate aerosol foam significantly improved scalp psoriasis symptoms in three patients by reducing itching and improving flaky patches within a four-week treatment period, confirming its efficacy and enhanced skin penetration compared to older formulations.
January 2011 in “Practical medicine” The authors reported that both finasteride and oral contraceptives with drospirenone had a significant therapeutic effect on women with polycystic ovary syndrome, leading to pregnancies in both treatment groups.
1 citations
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March 2024 in “International Journal of Dermatology” This case report describes a therapy-resistant folliculitis decalvans patient who showed nearly complete response with increased hair density after treatment with CO2 laser-assisted photodynamic therapy.
July 2017 in “Biology bulletin/Biology bulletin of the Russian Academy of Sciences” This study found that cultivating dermal papilla cells in spheroids or with valproic acid most effectively preserves their phenotype in vitro, compared to a monolayer culture with BMP6 and vitamin D3, which only produces a short-term effect.
July 2023 in “Developmental medicine and child neurology/Developmental medicine & child neurology” This study found that patients with Bachmann-Bupp syndrome treated with DFMO showed improvements in hair growth, muscle tone, and development.
9 citations
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March 2017 in “JAAD Case Reports” This case report describes erosive pustular dermatosis of the scalp triggered by contact dermatitis from a glued-on hair piece, marking the first instance of this specific cause.
8 citations
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July 2018 in “European Journal of Dermatology” A medication may help with hair growth in psoriasis, and a skin condition might be linked to a specific bacteria.
68 citations
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August 2014 in “Stem Cells Translational Medicine” This study found that composite skin constructs containing dermal papilla cells promoted better skin healing and hair regeneration in nude mice, highlighting their role in tissue-engineered skin for severe injuries.
January 2024 in “Dermatologic Surgery” This abstract pertains to a dermatology-related academic profile without reporting any specific study findings. Results or research details are not provided.
April 2025 in “Digital Commons - East Tennessee State University (East Tennessee State University)” This study reviewed recent literature on Long COVID, examining cardiopulmonary, dermatological, neurological, and rheumatological symptoms and identifying risk factors like severe initial infection, comorbidities, and lack of prior vaccination.
64 citations
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March 1984 in “Journal of steroid biochemistry/Journal of Steroid Biochemistry” In this study, cyproterone acetate combined with estradiol dramatically improved hirsutism symptoms and significantly reduced plasma testosterone and androstenedione levels in patients over periods of up to three years.
7 citations
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July 2005 in “Journal of Dermatological Science” This study identified a gene transcript overexpressed in dermal papilla cells, showing strong similarity to a mouse gene associated with adipose tissue in bombesin receptor subtype-3-deficient mice.
1 citations
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August 2021 This study found that biomimetic dermal papilla spheres cultured in a specific microenvironment can partially restore hair-inducing ability in high-passage dermal papilla cells in nude mice, resembling the characteristics of primary cells.
June 2010 in “Journal of Chemical Crystallography” This study determined the crystal structure and conformation of synthesized 17x-Acetoxy-pregn-4,6-diene-3,20-dione, revealing specific molecular interactions and structural details in an orthorhombic crystal system.
8 citations
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June 2012 in “PloS one” This study found that the Plcd3(mNab) mutation in mice worsens the alopecia caused by Plcd1 loss, suggesting synergistic effects between Plcd1 and Plcd3 on hair follicle health.