7 citations
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December 2015 in “PloS one” In this study, cryopreserved mouse whisker hair follicles were shown to maintain their hair growth potential and functional recovery, with DMSO being more effective than glycerol for cryopreservation.
April 2018 in “Journal of Investigative Dermatology” In this study, the authors identified a role for hair follicles in regulating the formation and sympathetic innervation of arrector pili muscles, influencing hair follicle stem cell activity and potentially explaining hair loss associated with beta-blockers and androgenic alopecia.
June 2022 in “Zenodo (CERN European Organization for Nuclear Research)” This study found that methanolic extracts from Capparis decidua fruits showed significant in vitro clot lysis activity, indicating potential as a safer anti-thrombotic alternative, but more research is needed to confirm its effectiveness in vivo.
20 citations
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December 2021 in “Plants” This review concludes that Tamarix aphylla, used traditionally for ailments such as tuberculosis and hepatitis, demonstrates various pharmacological activities, including antidiabetic and wound-healing effects, but stresses the need for further research to confirm its safety and effectiveness in humans.
13 citations
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August 1995 in “British Journal of Dermatology” This study found that dapsone treatment for severe alopecia areata resulted in hair regrowth rates similar to spontaneous recovery, making it significantly less effective than topical immunotherapy.
September 2024 in “Current Drug Delivery” This study found that Ginger-Derived Extracellular Vesicles (GDEVs) may promote hair growth and reduce inflammation in an alopecia mouse model.
October 2024 in “Current Issues in Molecular Biology” In this experimental study, the researchers observed that Platycladus orientalis leaf extract promoted hair growth by enhancing dermal papilla cell proliferation and increasing growth factor expression, particularly through ACK1 activation and modulation of Wnt/β-catenin signaling pathways in cultured human cells and a 12-week topical application.
This study reports that 70% ethanol extracts of Houttuynia cordata and Calendula officinalis may promote hair growth activity by not being toxic to fibroblasts or dermal papilla cells and stimulating lipid precursor cell differentiation in vitro.
1 citations
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July 2022 in “Plant Cell, Tissue and Organ Culture (PCTOC)” This study identified that the biosynthetic pathways for coumestans in Eclipta prostrata are derived from acetate and shikimate pathways, while phenylpropanoid biosynthesis is exclusively from the shikimate pathway.
August 2026 in “Tạp chí Dược liệu” In this study, Curcuma longa, Eclipta prostrata, and Pogostemon cablin extracts were found to significantly promote human dermal papilla cell proliferation, while Chrysanthemum indicum and Eclipta prostrata exhibited strong antioxidant activities, indicating their potential for hair growth-promoting formulations.
2 citations
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March 2010 in “European journal of dermatology/EJD. European journal of dermatology” This case report describes a 5-year-old girl with trichorrhexis nodosa and highlights the presence of isolated curly hairs on her scalp despite hair loss over four months.
1 citations
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February 1938 in “Archives of Dermatology” This piece presents a case study of a woman with diffuse alopecia, suggesting a potential link to a chronic focus of infection rather than acute fever.
2 citations
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May 2022 in “Advanced therapeutics” This study reported that a novel vasodilator drug called TOP-M119, when delivered using a specially designed dissolving microneedle system, showed enhanced targeting of hair follicles and effectiveness in treating alopecia, demonstrated through in vitro, ex vivo, and in vivo studies involving mouse skin.
January 2010 in “Life Science Alliance” This study found that in Vdr-knockout mice, hair follicles fail to complete the catagen stage, leading to persistent epithelial strands and subsequent hair loss.
March 2023 in “Natural product sciences” This study demonstrated that Celtis choseniana Nakai may help alleviate androgenic alopecia by enhancing hair regrowth and activating Wnt/β-catenin signaling in both a mouse model and cultured human cells.
1 citations
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January 2002 in “The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology” This study found that several natural extracts, including Polygonum multiflorum Thunb and Terminalia chebula Retz., promoted hair growth in mouse models but showed limited effectiveness on human hair growth in vitro.
45 citations
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July 2006 in “Journal of Investigative Dermatology” This study found that doxorubicin disrupts hair-follicle-associated blood vessels, which may contribute to hair follicle dystrophy and alopecia in mice, but hair-follicle stem cells remained unaffected.
July 2021 in “International journal of dermatology, venereology and leprosy sciences” This study found that diphenylcyclopropenone (DPCP) was more effective and better tolerated than dinitrochlorobenzene (DNCB) in promoting hair regrowth in patients with alopecia areata.
December 2025 in “JAAD reviews.” This research discussed the historical use of plants as dermatologic remedies and how some botanicals independently gained recognition for their medicinal properties across cultures, contributing to the field of pharmacognosy and modern skincare.
5 citations
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March 2016 in “Experimental and molecular pathology” In mouse models of alopecia areata, this study found increased dilation of lymphatic vessels in affected mice, with associated changes in gene expression related to vascular growth and immune cell movement.
10 citations
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October 2019 in “Acta Pharmaceutica” This review discusses the use of herbal medicinal products for treating chronic skin diseases like vitiligo and psoriasis and reports no new clinical results; the authors emphasize the need for standardized extracts and further research.
7 citations
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October 2015 in “Julius Kühn-Institut” This study found that finasteride, which alters plant brassinosteroid metabolism, significantly reduced sporulation of the downy mildew pathogen in grapevines, unlike azole fungicide treatments.
March 2014 in “Journal of The American Academy of Dermatology” Azathioprine may help with severe hair loss, a new topical treatment could counteract hair thinning, and trichoscopy can diagnose hair-pulling disorder effectively.
This study observed that vitamin D deficiency is linked to a weakened immune system and may promote autoimmune inflammation in individuals with diffuse alopecia, where hair loss happens throughout the scalp.
36 citations
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May 2005 in “BMC dermatology” This study found that topical diphenylcyclopropenone was effective in treating severe alopecia areata but had a high relapse rate and was often accompanied by side effects like eczema and lymphadenopathy.
February 2026 in “Nano Research” This study developed a dissolvable microneedle system delivering specific molecules to remodel lymphatic networks and normalize metabolic processes, which accelerated hair growth and activated hair follicle stem cells in a mouse model of androgenetic alopecia.
14 citations
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March 2000 in “Journal of Zoo and Wildlife Medicine” This study identified a new Demodex species causing demodicosis in a zoo koala, successfully treated with daily oral ivermectin.
1 citations
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March 2023 in “Portuguese Journal of Dermatology and Venereology” This case report describes a 15-year-old girl with alopecia universalis who experienced scalp hair regrowth after self-medicating with cannabis, suggesting it may have potential as a treatment for autoimmune diseases like alopecia areata.
January 1998 in “Proceedings of the British Society of Animal Science” This study examined the role of biotin deficiency and adequacy on cell proliferation and DNA synthesis in isolated mohair follicles.
June 2026 in “Frontiers in Cell and Developmental Biology” In this study, researchers used single-cell RNA sequencing to map the hair follicle microenvironment in fine-wool sheep, identifying specific cell types and gene expressions that influence wool fiber diameter, with dermal papilla cells playing a significant role in hair follicle development.