1 citations
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July 2025 in “Journal of Photochemistry and Photobiology B Biology” Photobiomodulation helps protect hair follicle cells from damage caused by DHT.
2 citations
,
March 2005 in “Journal of the American Academy of Dermatology” Equol may help with antiaging and skin health by boosting collagen and blocking certain hormones.
November 2016 in “Universiti Putra Malaysia Institutional Repository (Universiti Putra Malaysia)” This study found that Dendrobium sabin flower extracts, especially the methanolic one, demonstrated strong antioxidant and anti-aging properties without significant toxicity, suggesting its potential in treating photo-induced skin aging.
83 citations
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December 2001 in “Journal of Investigative Dermatology” Minoxidil boosts hair growth by targeting adenosine and possibly sulfonylurea receptor 2B.
1 citations
,
April 2022 in “Crystal Growth & Design”
January 2023 in “Skin appendage disorders” This review discusses the potential of low-dose oral minoxidil as a safe and effective treatment for certain hair disorders, including alopecia, but reports no new clinical results.
9 citations
,
February 2011 in “Revista Brasileira de Farmacognosia” This study reported that phytochemicals SA-4 and SA-6 from Tridax procumbens exhibited a dose-related immunostimulatory effect on mice, suggesting their potential as immunostimulators.
1 citations
,
July 2024 in “JAAD International” This article discusses the off-label use of low-dose oral minoxidil for alopecia and reports no new clinical findings, noting its presumed mechanism is enhancing hair follicle microcirculation with minimal blood pressure effects.
1 citations
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June 2025 in “Journal of Cellular and Molecular Medicine” This study explored the role of plant-derived monomers in reversing grey hair, finding that compounds like fraxinol and morin may stimulate melanin production and tyrosinase activity, suggesting potential therapeutic benefits, although further evaluation of their safety and efficacy is needed.
10 citations
,
November 2017 in “Letters in drug design & discovery” This paper discusses a structure-based analysis to find new BRD4 inhibitors, identifying finasteride and amentoflavone as promising candidates for BET inhibition.
January 2026 in “Figshare” In this study, women with female pattern hair loss using low-dose oral minoxidil reported significant improvements in hair loss severity and quality of life, with most experiencing mild or moderate unwanted hair growth but continuing treatment regardless.
17 citations
,
June 2019 in “Cellular signalling” Minoxidil treatment in mice preserved the integrity of elastic lamellae and improved arterial biomechanical properties, especially in females, suggesting it could be an anti-arterial aging agent potentially suitable for female-targeted therapies.
34 citations
,
July 2011 in “Journal of Dermatological Treatment” This study found that a combination of 5% hexane extract of Curcuma aeruginosa and 5% minoxidil slowed hair loss and increased hair growth in men with androgenetic alopecia.
2 citations
,
January 2011 This study found that topical 5% aqueous extract of Trichosanthes dioica R. leaves significantly promoted hair growth in rats compared to both a control and minoxidil treatment.
March 2025 in “Actas Dermo-Sifiliográficas” In this retrospective study of patients with androgenetic alopecia, oral minoxidil at doses greater than 5 mg daily improved hair density by 10-30% in most cases, but 24.6% experienced adverse effects, prompting a need for further research on its safety and optimal dosage.
40 citations
,
July 1995 in “Toxicologic Pathology” In this study, glyburide prevented or significantly reduced cardiovascular lesions in dogs caused by minoxidil by blocking its hemodynamic effects, suggesting the toxicity is related to these profound effects rather than direct heart toxicity.
This study reported that chemically modified cellulose from pineapple waste effectively created nanoparticles for minoxidil delivery with high encapsulation efficiency and prolonged release, potentially useful for androgenic alopecia treatment.
March 2025 in “Jurnal Farmamedika (Pharmamedica Journal)” In this study, Indonesian spices were screened in silico for their potential to inhibit MMP9 and TNFα, which are involved in chronic diabetic wounds, and procyanidin was identified as the most promising therapeutic candidate due to its low binding energy to both proteins.
April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology” In this study, researchers found that Derinat treatment in mice maintained the hair cycle in the anagen phase and reduced TRPCs-mediated intracellular ROS accumulation, potentially improving hair growth by altering the skin microenvironment.
1 citations
,
January 2022 in “Journal of Cosmetic Dermatology” This study found that combining oral vitamin D with topical minoxidil improved female pattern hair loss more effectively than either treatment alone.
2 citations
,
April 2016 in “DOAJ (DOAJ: Directory of Open Access Journals)” This study found that a novel saw palmetto supercritical CO2 extract effectively inhibits 5α-reductase type II in vitro, suggesting its potential for promoting prostate health in benign prostatic hyperplasia.
December 2023 in “Research Square (Research Square)” In this study, researchers using molecular docking techniques found that 12-Methoxy carnosic acid from rosemary shows promising potential as a natural inhibitor of the 5 alpha reductase enzyme, which is involved in hair loss, suggesting its efficacy compared to finasteride.
March 2025 in “Journal of Clinical Medicine” This study reviewed adverse events associated with low-dose oral minoxidil for treating alopecia, finding hypertrichosis and fluid retention as common, typically manageable side effects without needing treatment discontinuation.
September 2005 in “Eclética Química” This study demonstrated that a photometric flow titration method using KMnO4 and minoxidil provided recovery rates of 97.6 to 102.8% for commercial samples, with relative errors of 3.5 to 4.0% compared to chromatographic procedures.
July 2023 in “International Journal of Molecular Sciences” In this study, Trapa bispinosa Roxb. pericarp extract demonstrated inhibitory effects on 5α-reductase activity both in vitro using LNCaP cells and in vivo in a mouse model of benign prostatic hyperplasia, suggesting its potential role in managing the condition.
17 citations
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May 1975 in “Clinical Pharmacology & Therapeutics”
3 citations
,
January 2018 in “Biomedical dermatology” This study found that epigallocatechin-3-gallate (EGCG) may reduce paclitaxel-induced apoptosis in human dermal papilla cells by regulating microRNA expression related to apoptosis and cell proliferation.
January 2023 in “Bioorganičeskaâ himiâ” This study found that a new deoxycholic acid derivative may offer a similar prostatoprotective effect to finasteride with lower toxicity in rat models.
This study found that the Padina arborescens extract and its component MOGG may prevent hair loss by inhibiting 5α-reductase activity, promoting cell proliferation, opening the KATP channel, and increasing PGE2 production in laboratory settings.
September 2019 in “Journal of Investigative Dermatology” This study observed that PCE-DP may improve skin pigmentation by increasing epidermal turnover and inhibiting melanin uptake and inflammation in human epidermal keratinocytes.