May 2013 in “DOAJ (DOAJ: Directory of Open Access Journals)” This study found that a multimodal microemulsion containing minoxidil, diclofenac, and tea tree oil was significantly more effective and stable than minoxidil alone in treating androgenic alopecia over a 32-week period.
2 citations
,
June 2017 in “Journal of biomedicine and translational research” In this study, Oligonol® was shown to regulate gene expression related to cell proliferation and inflammation in human dermal papilla cells.
1 citations
,
October 2025 in “Current Issues in Molecular Biology” This research found that escin, when applied topically, enhances blood flow in human skin and promotes changes in endothelial cell signaling pathways, suggesting potential benefits for improving cutaneous microcirculation.
8 citations
,
March 2018 in “Expert Review of Respiratory Medicine” This article reviews the potential of inhalation therapy to restore pulmonary elastin fibers in COPD patients and highlights the need for studies to test its feasibility; it reports no new research findings.
January 2009 in “Journal of Jilin Medical College” This study found that SDG did not significantly affect prostate weight in rats with BPH, but it may reduce serum PAP activity and alter prostate tissue changes induced by Testosterone Propionate.
6 citations
,
February 2020 in “Journal of Natural Products” In this chemical investigation, cyclospongiaquinone 1 from the sponge Verongula cf. rigida showed strong steroid 5α-reductase inhibitory activity, comparable to that of finasteride.
25 citations
,
September 2020 in “Molecules” In this study, quercitrin was reported to promote hair growth and cell viability in cultured human dermal papilla cells by enhancing cellular energy metabolism and growth factor production via MAPK/CREB signaling.
6 citations
,
January 2021 in “Journal of The American Academy of Dermatology” This letter discusses adverse events related to low-dose oral minoxidil for alopecia, highlighting age-related risks and stressing the importance of contraindication awareness with no new clinical results presented.
68 citations
,
September 1990 in “Biochemical Pharmacology” This study found that minoxidil is bioactivated through sulfation by the phenol-sulfating form of phenol sulfotransferase in human liver.
January 2026 in “Journal of Dermatological Science” This research observed that Salvianolic acid B (Sal B) significantly promoted hair regeneration in vivo and in vitro, outperforming minoxidil in a mouse model of androgenetic alopecia, by activating Wnt/β-catenin and mTORC2/Akt pathways and upregulating MMPs and MAPKs.
3 citations
,
December 2024 in “Biomolecules & Therapeutics” This study found that Tanshinone I and Tanshinone IIA from Salviae Miltiorrhizae Radix inhibited Nox activity heightened by testosterone in a mouse model, reducing H₂O₂ production and cell apoptosis, and reversing testosterone-induced hair growth suppression, suggesting their potential as treatments for androgenetic alopecia.
9 citations
,
August 2024 in “Journal of Drugs in Dermatology” In this study, researchers found no evidence of increased prevalence of pericardial effusions in alopecia patients treated with low-dose oral minoxidil compared to those not receiving minoxidil, based on point-of-care ultrasound evaluations.
October 2023 in “International Journal of Pharmaceutics” This study found that ethosome-loaded minoxidil and tocopherol acetate improved hair regeneration and regulated the microenvironment around hair follicles better than commercial minoxidil in androgenic alopecia model mice, showing promise as a treatment strategy.
July 2022 in “The journal of investigative dermatology/Journal of investigative dermatology” This study suggests that combining Silybum marianum extract, Manganese PCA, and Lespedeza capitata extract may help improve hair growth and anchorage by targeting specific signaling pathways in human dermal papilla cells.
19 citations
,
May 1979 in “Archives of internal medicine” Minoxidil effectively lowers blood pressure and initially increases plasma renin activity without raising aldosterone levels.
December 2024 in “Globus: an international journal of medical science, engineering and technology.” This study found that 10% Citrus aurantium peel oil significantly promoted hair growth in ICR mice by reducing the time needed for hair growth initiation and completion, and by increasing hair length, follicle diameter, and count, showing potential as a hair growth agent.
July 2025 in “Journal of Investigative Dermatology” Low-dose oral minoxidil is safe for the heart in the short term for hair loss patients.
53 citations
,
January 1993 in “Biochemical Pharmacology” This study reports a method for efficiently synthesizing chromeno-pyrimidine-N-oxides in good to excellent yields, confirmed by X-ray analysis, through a reaction between 4-chloro-3-formylcoumarin and aromatic carboximide oximes.
September 2022 in “JAAD Case Reports” This case report discusses rare but serious cardiac complications, including pericarditis and edema, observed with low-dose oral minoxidil for hair loss, highlighting the need for cautious prescribing, especially in high-risk patients.
13 citations
,
September 2024 in “Frontiers in Pharmacology” This review highlighted the pharmacological potential of Mor, noting its protective effects on the kidneys, liver, bones, nervous system, heart, digestive system, skin, and lungs, as well as its anti-obesity and anti-inflammatory properties, revealing areas for future research.
76 citations
,
February 2015 in “Industrial Crops and Products” This study identified over 40 phytochemical compounds in the leaves and flowers of Bituminaria bituminosa, predominantly glycosylated flavonoids from apigenin, using advanced chromatographic techniques.
28 citations
,
April 2008 in “Journal of Inclusion Phenomena and Macrocyclic Chemistry” This study identified a weak interaction between minoxidil and ß-cyclodextrin in solution, forming an inclusion complex with a 1:1 molar ratio.
January 2024 in “Reproductive toxicology” This study found that hesperidin, a bioflavonoid, mitigated the negative effects of finasteride on sperm health and testicular structure in male Wistar rats by reducing oxidative stress and apoptosis and supporting testicular antioxidant capacity.
3 citations
,
June 2024 in “Immunopharmacology and Immunotoxicology” This study found that cardamonin can reduce inflammation in TNF-α-stimulated human periodontal ligament cells by suppressing specific cytokines and chemokines and inhibiting key inflammatory signaling pathways.
25 citations
,
December 1974 in “Clinical Pharmacology & Therapeutics” Propranolol affects heart rate and renin levels in minoxidil-treated patients.
1 citations
,
September 2025 in “Archivio Italiano di Urologia e Andrologia” In this study, the combination of Serenoa repens extract with Phenolmicin P3 and Bosexil suppositories significantly improved lower urinary tract symptoms and decreased PSA levels in patients with benign prostatic obstruction-related symptoms.
June 2023 in “Journal of Natural Remedies” This study found that the methanolic extract of Hibiscus rosa sinensis exhibits promising 5α-reductase inhibitory activity, suggesting its potential use in the treatment of androgenic conditions like male pattern hair loss and benign prostatic hyperplasia.
September 2025 in “International Journal of Innovative Technologies in Social Science” This study found that low-dose oral minoxidil (≤5 mg/day) effectively increased hair number and diameter in men and women with androgenetic alopecia, and was generally well-tolerated with mostly mild adverse effects, although serious complications were rare and associated mainly with pre-existing heart conditions.
July 2026 in “Dermatology Practical & Conceptual” In this study, the researchers observed that gastrointestinal side effects, such as flatulence and abdominal discomfort, were more common in patients taking low-dose oral minoxidil, especially among males and those using concurrent vasodilators.