7 citations
,
November 2006 in “Journal of immunological methods” This study found that the novel dot-block method can effectively measure early- and advanced-glycation products in hair, suggesting its potential for monitoring diabetes progression and other chronic conditions.
9 citations
,
May 2021 in “Molecules” This review discusses indole-based bifunctional aldose reductase inhibitors and antioxidants for diabetic complications and chronic inflammation-related pathologies, but reports no new clinical results.
74 citations
,
April 2002 in “PubMed” This study found that the oral contraceptive containing drospirenone (EE/DRSP) was as effective as EE/CPA in reducing acne lesions, sebum production, and hair growth in women with acne.
2 citations
,
January 1999 in “Dermatology”
The document concludes that scientists created various steroids with different properties, including a more effective semi-synthetic vitamin D.
November 1968 in “Journal of the American Pharmaceutical Association” 14 citations
,
May 2005 in “Steroids” This study describes the synthesis of finasteride from 4-androstene-3,17-dione in a seven-step process with an overall yield of 18.6%.
January 1983 in “Elsevier eBooks” This article reviews the discovery and various physiological effects of cyproterone acetate, reporting its established indications for several androgen-driven conditions but providing no new clinical data.
25 citations
,
October 2019 in “Journal of Endocrinological Investigation” This study reported that both drospirenone and chlormadinone acetate oral contraceptives had similar beneficial effects on clinical, metabolic, and hormonal parameters in women with polycystic ovary syndrome over six months.
3 citations
,
January 2015 in “Sen i Gakkaishi” This study reported that keratin films lacking keratin-associated proteins showed different appearance, structure, and color deposit properties compared to conventional keratin films, suggesting potential for evaluating hair damage.
May 2022 in “Current Enzyme Inhibition” This study found that the synthesized compound 7b exhibited higher 5α-reductase inhibitory activity, increased solubility, and dissolution compared to finasteride, suggesting its potential as a lead compound for benign prostatic hyperplasia treatment.
January 2013 in “The Thai Journal of Pharmaceutical Sciences”
21 citations
,
January 2010 in “JOURNAL OF HEALTH SCIENCE” This study found that abietic acid from pine resin more effectively inhibits testosterone 5α-reductase than several plant extracts, suggesting potential for treating androgen-dependent diseases.
7 citations
,
September 1988 in “Baillière's clinical obstetrics and gynaecology” This article discusses the mechanisms of hirsutism and acne in women, highlighting cyproterone acetate with ethinyloestradiol as an effective anti-androgen therapy in the UK, but it reports no new clinical findings.
3 citations
,
May 2020 in “Acta pharmaceutica” The researchers reported that protocatechuic acid reduced melanin synthesis and enhanced antioxidant activity in cultured human hair follicle melanocytes, indicating potential for skin whitening applications.
118 citations
,
May 2015 in “European journal of pharmaceutics and biopharmaceutics” This study found that the pH-sensitive hydrogel HECHA13, containing isoliquiritigenin, effectively inhibited the growth of Propionibacterium acnes and showed promise for transdermal delivery in acne treatment.
January 2025 in “International Journal of Cosmetic Science” This study found that citric acid treatment can significantly improve the structural integrity and mechanical properties of chemically treated hair, reducing damage by increasing keratin crosslinking density and decreasing crystallized calcium soaps, with varying effectiveness depending on the type of chemical treatment.
59 citations
,
August 2014 in “International Journal of Biological Macromolecules” In this study, the researchers optimized the extraction conditions for crude polysaccharide from Hibiscus rosa-sinensis leaves, achieving a yield of 9.66% and demonstrated strong antioxidant activities in vitro.
13 citations
,
August 1985 in “The Journal of Dermatology” This study identified a monoclonal antibody, HKN-2, that recognizes specific cells in human skin and may indicate a common antigenic determinant between hair and other skin epithelial tissues.
11 citations
,
November 2015 in “Journal of Functional Foods” This study found that the ethyl acetate fraction of Hibiscus rosa sinensis petals significantly reduced serum glucose and glycated hemoglobin levels in diabetic rats, with effects comparable to metformin.
12 citations
,
November 2024 in “International Journal of Molecular Sciences” This study found that hydroxytyrosol significantly alleviated acute liver injury in mice by suppressing inflammation and targeting the TNF-α/PI3K/AKT signaling pathway.
This study found that cyproterone compound is not more effective than oral isotretinoin in treating nodulocystic acne in adult females with SAHA syndrome or cutaneous hyperandrogenism, suggesting isotretinoin may be preferable due to its established effectiveness in reducing acne lesions.
1 citations
,
December 1970 in “European journal of endocrinology” This study reports experience treating 140 women with hirsutism and other virilism signs using cyproterone acetate and ethinyl estradiol, focusing on those treated for over five months.
1 citations
,
March 2004 in “Patty's Toxicology” This article reviews the properties, uses, and toxic effects of eleven unsaturated halogenated hydrocarbons, highlighting the risks associated with compounds like dichloroacetylene, allyl chloride, and vinyl chloride, and reports no new experimental findings.
May 2026 in “Frontiers in Pharmacology” In this study, DOP treatment improved hair regrowth in androgenetic alopecia by altering local steroid metabolism and follicular morphology.
42 citations
,
May 2003 in “Mini-reviews in Medicinal Chemistry” This study found that newly synthesized steroidal trienones demonstrated stronger 5α-reductase inhibitory activity compared to dienones in various biological models, suggesting potential for developing enhanced antiandrogenic drugs.
January 2007 in “The Journal of Pharmaceutical Practice” This study concluded that a synthesis process for finasteride from pregnenolone acetic ester is inexpensive, simple, and achieves a good yield of 36.5%.
4 citations
,
December 2024 in “International Journal of Molecular Sciences” This study found that extracts from Hom Thong banana peels, rich in phenolic compounds, may inhibit melanin production in human and mouse melanoma cells, showing potential as anti-melanogenic agents comparable to standard treatments like arbutin and kojic acid.
6 citations
,
October 2023 in “Pharmaceuticals” This study found that the extract of Eclipta prostrata L. demonstrated high antioxidant and anti-acetylcholinesterase activities, moderate inhibition of enzymes linked to diabetes, and favorable ADMET properties, suggesting potential cognitive and diabetes management benefits.
April 2021 in “Research Square (Research Square)” This study found that the new cocrystal formulation KET-PABA improved the antimycotic efficiency of ketoconazole and induced an anti-inflammatory response without causing skin sensitization in mice.