Hydroxytyrosol Alleviates Acute Liver Injury by Inhibiting the TNF-α/PI3K/AKT Signaling Pathway via Targeting TNF-α Signaling

The study demonstrates that hydroxytyrosol (HT) can alleviate acute liver injury (ALI) in mice by inhibiting the TNF-α/PI3K/AKT signaling pathway. Conducted on 50 male Balb/C mice, the research showed that HT reduced liver damage and inflammation by downregulating inflammatory markers such as TNF-α and IL-6. HT also improved liver function by decreasing serum ALT, AST, and LDH activities and ameliorating pathological conditions. These findings suggest HT's potential as a therapeutic agent for ALI, with future research needed to explore its effects on liver fibrosis for long-term treatment strategies.