Hydroxytyrosol Alleviates Acute Liver Injury by Inhibiting the TNF-α/PI3K/AKT Signaling Pathway via Targeting TNF-α Signaling

    November 2024 in “ International Journal of Molecular Sciences ”
    Zhining Gao, Hui Dai, Qinqin Zhang, Fan Yang, Chenxi Bu, Suiqing Chen
    Studysummary This study found that hydroxytyrosol significantly alleviated acute liver injury in mice by suppressing inflammation and targeting the TNF-α/PI3K/AKT signaling pathway.
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    The study demonstrates that hydroxytyrosol (HT) can alleviate acute liver injury (ALI) in mice by inhibiting the TNF-α/PI3K/AKT signaling pathway. Conducted on 50 male Balb/C mice, the research showed that HT reduced liver damage and inflammation by downregulating inflammatory markers such as TNF-α and IL-6. HT also improved liver function by decreasing serum ALT, AST, and LDH activities and ameliorating pathological conditions. These findings suggest HT's potential as a therapeutic agent for ALI, with future research needed to explore its effects on liver fibrosis for long-term treatment strategies.
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