112 citations
,
January 2004 in “The International journal of developmental biology” This study found that feather patterning is primarily self-organizing and dynamic, relying on both genetic and epigenetic controls, with implications for similar processes like fingerprints and pigmentation.
90 citations
,
July 2014 in “Conservation Physiology” This study found that hair cortisol concentration in free-ranging brown bears is influenced by handling methods, body condition, and potentially both short- and long-term stressors.
32 citations
,
September 2018 in “Journal of pharmaceutical sciences” This study extended a skin diffusion model to include a porous pathway, effectively explaining the permeability of both polar and lipophilic solutes through the stratum corneum.
5 citations
,
September 2023 in “International Journal of Molecular Sciences” This study found that FucoPol hydrogel membranes can effectively deliver model drugs such as caffeine and diclofenac sodium via different loading methods, with notable mechanical and release properties, suggesting their potential as platforms for topical drug delivery.
1 citations
,
February 2025 in “Journal of Anatomy” This study observed that during the postnatal development of gray short-tailed opossums, skin transitions from facilitating gas exchange through a dense capillary network at birth to supporting thermoregulation, with significant changes in skin thickness and structure occurring by 35 days old.
1 citations
,
October 2022 in “Iet Nanobiotechnology” This study explored a new dutasteride nanocarrier for alopecia therapy, concluding that ingredient concentration is key to achieving the optimal particle size, stability, and skin permeation for extended drug release.
44 citations
,
February 2023 in “Cell” In this study, researchers found that human fingerprint ridges are formed through a modified hair follicle developmental process and spatial patterns influenced by specific signaling pathways.
13 citations
,
November 2017 in “BMC Veterinary Research” This study suggests that topically applied fusidic acid may penetrate only the most superficial layers of canine skin but can reach sufficient concentrations to potentially treat infections caused by pathogenic staphylococci.
1 citations
,
June 2007 in “Almustansiriya journal of pharmaceutical sciences/Al-Mustansiriyah journal of pharmaceutical sciences” This study found that a cimetidine 10% cream with sodium lauryl sulphate significantly increased drug diffusion through mouse skin and showed promise in treating warts in a preliminary clinical trial.
70 citations
,
June 1993 in “Biochemistry” This study found that the binding of finasteride to the enzyme 5a-reductase occurs at a slower rate than previously assumed, complicating the estimation of its real inhibitory constant.
61 citations
,
June 2010 in “European Journal of Pharmaceutics and Biopharmaceutics” This study found that liposomes coated with cationic polymers, chitosan and Eudragit EPO, showed improved physicochemical stability and enhanced skin diffusion of aciclovir and minoxidil compared to uncoated liposomes.
9 citations
,
March 2024 in “Journal of Biomaterials Applications” This study developed dissolving microneedles using specific polymers for transdermal delivery of rizatriptan benzoate, demonstrating improved drug skin penetration and significant alleviation of migraine symptoms in vivo compared to passive diffusion, suggesting potential advantages over conventional treatment methods for acute migraine.
January 2026 in “Drug Delivery and Translational Research” This study investigated the integration of crystal engineering and microneedle technology for androgenetic alopecia treatment, finding that microneedles loaded with newly developed Kopexil multicomponent crystals reduced drug diffusion rates in vitro compared to standard formulations.
August 2022 in “Scholars academic journal of pharmacy” This study involved formulating an invasome gel loaded with clotrimazole for treating fungal infections and assessed its various properties like spreadability and in vitro drug diffusion.
25 citations
,
November 2012 in “Thermochimica Acta” This study found that lipid extraction increased water diffusion in wool and hair fibers; the effect was more pronounced in hair, indicating lipids are crucial for water permeability.
2 citations
,
November 2024 in “Aesthetic Surgery Journal” This study found that vibration anesthesia significantly reduced pain during botulinum toxin injections for masseter reduction without affecting the injection's diffusion or causing adverse effects, and high patient satisfaction was also reported.
61 citations
,
May 2014 in “International journal of pharmaceutics” This research describes a process for producing caffeine nanocrystals, which may enhance skin penetration by accumulating in hair follicles and maintaining stability for two months, paving the way for in vivo testing.
39 citations
,
August 2017 in “Colloids and Surfaces B: Biointerfaces” This study found that 50-nm PLGA nanoparticles delivered with iontophoresis enhanced skin permeation of indomethacin in rats more effectively than 100-nm nanoparticles, suggesting improved targeting of hair follicles.
12 citations
,
August 2012 in “ISRN Analytical Chemistry (Print)” This review discusses various chemical and instrumental methods for determining macrolides and reports no new experimental results.
July 2026 in “International Journal of Aquatic Research and Environmental Studies” In this experimental study, researchers developed and optimized metformin-loaded mucoadhesive microspheres for sustained anti-hyperglycemic and anticancer activity, demonstrating high entrapment efficiency, enhanced α-amylase and α-glucosidase inhibition, improved cytotoxicity against breast cancer cells, and promising stability.
55 citations
,
June 2013 in “Dermatologic Surgery” This review discusses the use of ablative and nonablative fractional resurfacing for enhanced topical drug delivery in dermatology and reports no new clinical results; further studies are needed to explore these methods.
49 citations
,
September 2008 in “International journal of pharmaceutics” This study suggests that artificial sebum L may serve as an effective substitute for human sebum in drug transport studies, due to its similar physicochemical properties.
29 citations
,
September 2024 in “AAPS PharmSciTech” This review explores the use of skin penetration enhancers like Transcutol® in various formulation systems, discussing their mechanisms and effectiveness in improving transdermal drug delivery without breaching the skin.
29 citations
,
August 2005 in “Biopolymers” In this study, researchers found that L-cysteine interacted electrostatically with anionic ions on the surface of keratin fibers in human hair, reducing the rate of disulfide bond disconnection at pH 9.0.
26 citations
,
March 2014 in “International journal of pharmaceutics” This study confirmed that the novel solid lipid microparticle formulation of adapalene demonstrated follicular penetration potential and targeted particle erosion in sebum in in vitro tests.
21 citations
,
January 2012 in “Biological and Pharmaceutical Bulletin” This study found that using a combination of iontophoresis and liposomal delivery facilitated the effective intradermal administration of superoxide dismutase in rats, reducing oxidative skin damage from UV exposure.
3 citations
,
December 2000 in “International Journal of Cosmetic Science” This study established that a human epidermal model can be utilized to assess 5alpha-reductase activity and evaluate enzyme modulators, such as finasteride, for dermatological applications.
October 2019 in “Skin appendage disorders” This study revisits and reproduces Felix Pinkus' concept of the vitreous membrane in hair follicles, suggesting these structures may play a role in differentiation or nutrition due to their location in metabolically dynamic regions.
January 2017 in “Qucosa (Saxon State and University Library Dresden)” This study found that plasma protein binding significantly contributes to the shifts in glucocorticosteroid concentration ratios among blood, saliva, and hair, challenging prior assumptions about enzyme inactivation as the main factor.
4 citations
,
August 2011 in “Aktuelle Dermatologie” This study found that topical melatonin significantly improved hair density and reduced the severity of androgenetic alopecia in men and women.