Opportunities for Topical Antimicrobial Therapy: Permeation of Canine Skin by Fusidic Acid

The study investigated the permeation of fusidic acid (FA) through canine skin using various methods and found that FA primarily remained on the skin surface and within superficial layers, with significant concentrations in the follicular infundibulum but not in deeper structures or receptor fluids. The findings suggested that topical FA could be an effective treatment for superficial bacterial infections in dogs, particularly for conditions like superficial bacterial folliculitis, and recommended further in vivo evaluation to confirm these results.