15 citations
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December 2017 in “Journal of The European Academy of Dermatology and Venereology” This letter discusses potential pathogenetic links among frontal fibrosing alopecia, androgenetic alopecia, and fibrosing alopecia in a pattern distribution and reports no new clinical findings.
8 citations
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October 2020 in “Stem cell research & therapy” This study found that DNMT1 promotes adipogenesis in hair follicle stem cells by regulating the miR-214-3p/MAPK1/p-ERK1/2 pathway, suggesting potential applications in stem cell therapy.
February 2018 in “The American Journal of Gastroenterology” This study observed that intravenous ferric carboxymaltose did not inhibit the drug-induced reduction of inflammatory activity in patients with inflammatory bowel disease, as indicated by lower CRP levels.
35 citations
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August 2009 in “Differentiation” This study found that transcription factors HOXC13, LEF1, and FOXN1 repress DSG4 transcription, with the Notch pathway possibly involved in maintaining DSG4 expression in hair follicles.
5 citations
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February 2022 in “Molecular genetics & genomic medicine” This study identified genetic variants in the DSG4 gene associated with the autosomal recessive form of monilethrix in Chinese patients, expanding the understanding of its phenotypic spectrum and clinical features.
37 citations
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April 2019 in “Journal of The American Academy of Dermatology” This review assessed the effectiveness of various treatments for frontal fibrosing alopecia and found that intralesional steroids and 5α-reductase inhibitors showed the most positive outcomes in slowing or halting hair loss, though the lack of placebo-controlled studies and consistent outcome measures limits definitive conclusions.
April 2026 in “Frontiers in Pharmacology” This study revealed significant signals of drug-related cognitive disorders in several medications that lack relevant FDA label warnings, suggesting a need for increased clinical awareness and potential label updates.
January 2002 in “HAL (Le Centre pour la Communication Scientifique Directe)” In this study, researchers characterized a dehydroepiandrosterone hydroxylating enzyme system in hair follicles similar to the liver monooxygenase system, noting its inhibition by carbon monoxide and its dependence on NADPH.
3 citations
,
June 2016 in “JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology” This letter to the editor describes a case of postcast hypertrichosis in a patient with frontal fibrosing alopecia and reports no new research findings.
12 citations
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June 2017 in “Cell Cycle” This study observed that 5% minoxidil topical foam alters gene expression and signaling pathways in the scalp, providing insights into its mechanism of action in men with androgenetic alopecia.
February 2020 in “Spiral (Imperial College London)” This study found that duodenal mucosal resurfacing did not significantly improve insulin sensitivity or reproductive function in women with PCOS and insulin resistance compared to a sham procedure.
September 2017 in “Journal of Dermatology & Cosmetology” This study reports a case of frontal fibrosing alopecia associated with hepatitis C treatment involving interferon and ribavirin.
43 citations
,
July 2018 in “Journal of The European Academy of Dermatology and Venereology” This study found that a topical solution combining 0.25% finasteride with 3% minoxidil significantly improved hair growth, as measured by hair density, diameter, and global assessment, in men with androgenetic alopecia, compared to 3% minoxidil alone, over 24 weeks without systemic adverse effects reported.
42 citations
,
April 2011 in “Annals of Pharmacotherapy” This study found that long-term flutamide treatment reduced hair loss in women with female pattern hair loss, but liver-related dropouts were minimized at a very low dose of 62.5 mg/day.
16 citations
,
April 2014 in “Expert Opinion on Pharmacotherapy” This review discusses the pharmacological profile of teriflunomide for treating relapsing multiple sclerosis, highlighting its safety and effectiveness in reducing relapses and slowing disability progression, though direct comparisons with other oral medications are lacking.
June 2023 in “JAAD Case Reports” This article reviews the epidemiology of desmoplastic melanoma and reports no new clinical findings, emphasizing higher risks in chronically sun-exposed older males.
July 2025 in “Journal of Investigative Dermatology” Nelfb is essential for dermal fat development and survival.
1 citations
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May 2024 in “Skin Appendage Disorders” In this study, researchers analyzed trichoscopy findings in black patients with FFA to aid in precise diagnosis and treatment, highlighting the importance of understanding disease characteristics to improve hair care in this group.
September 2024 in “Journal of the American Academy of Dermatology” In this prospective, placebo-controlled study, the researchers observed a significant reduction in hair shedding in women after applying the combined topical treatment DA-OTC-002, containing synephrine and TAAR agonists, compared to placebo, showing a 62.5% average reduction with no reported adverse events.
April 2019 in “Journal of Investigative Dermatology” This study found that CYP11A1-derived vitamin D3 analogs inhibit fibroblast proliferation and decrease collagen production through VDR expression, showing potential antifibrotic and antiproliferative activity in human dermal fibroblasts.
January 2026 in “Preprints.org” In this study, researchers identified four novel variants in the FGF5 gene associated with the long-haired phenotype in dogs, suggesting additional unexplored genetic factors contribute to this trait beyond the known Lh1-Lh5 alleles.
April 2019 in “Journal of Investigative Dermatology” This study reported that mSKPs and DMSCs share similarities in biological characteristics but exhibit distinct transcriptome profiles, with mSKPs being more immune-related and DMSCs more associated with differentiation and disease pathways.
1 citations
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January 2022 in “Journal of Drug Delivery Science and Technology” This study successfully developed and optimized ethanol-free microemulsion systems for the transdermal delivery of finasteride, showing that the predicted optimal formulations had physicochemical characteristics close to estimated values, without significant damage to treated hair fibers.
2 citations
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July 2022 in “The Kaohsiung Journal of Medical Sciences” This study demonstrated that the immunomodulatory drug FTY720 may enhance the survival of allogeneic fat grafts in mice by reducing immune rejection and improving neovascularization.
June 2023 in “jurnal veteriner” In this study, Typhonium flagelliforme leaf-ethanolic extract combined with natural interferon was observed to stabilize body weight, inhibit tumor growth, and reduce mitosis, angiogenesis, and certain protein expressions in carcinogen-induced tumors in female mice, suggesting potential antitumor effects.
July 2021 in “British Journal of Dermatology” This case report describes a novel instance of scarring alopecia with features of frontal fibrosing alopecia in a patient with systemic sclerosis, suggesting a potential link between the two conditions not previously reported.
This case report describes a 5-year-old boy who developed generalized hypertrichosis after using 3% topical minoxidil for alopecia areata, which resolved six months after discontinuation.
April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that DNA-damaged hair follicle stem cells in mouse models do not show typical senescent markers but are dynamically expelled to maintain tissue health and prevent hair loss.
July 2024 in “Journal of Investigative Dermatology”
6 citations
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January 2018 in “Elsevier eBooks” This review outlines the current regulatory framework for cosmetics under the FD&C Act, highlighting that they are less strictly regulated than drugs, but notes potential future changes due to proposed legislations requiring stronger safety measures.